- abnormal cochlear inner hair cell morphology / MGI
- short inner hair cell stereocilia / MGI
- circling / MGI
- head bobbing / MGI
- impaired righting response / MGI
- deafness / MGI
- absent cochlear microphonics / MGI
- absent cochlear nerve compound action potential / MGI
- short vestibular hair cell stereocilia / MGI
- short cochlear hair cell stereocilia / MGI
- abnormal outer hair cell stereociliary bundle morphology / MGI
- abnormal auditory summating potential / MGI
- increased or absent threshold for auditory brainstem response / MGI
- decreased leukocyte cell number / MGI
- enlarged adrenal glands / MGI
- decreased body weight / MGI
- abnormal maternal nurturing / MGI
- hyperactivity / MGI
- abnormal gait / MGI
- impaired swimming / MGI
- increased circulating corticosterone level / MGI
- increased heart weight / MGI
- increased liver weight / MGI
- increased kidney weight / MGI
- cochlear hair cell degeneration / MGI
- cochlear inner hair cell degeneration / MGI
- abnormal cochlear outer hair cell morphology / MGI
- cochlear outer hair cell degeneration / MGI
- abnormal cochlear hair cell stereociliary bundle morphology / MGI
- decreased outer hair cell stereocilia number / MGI
- short outer hair cell stereocilia / MGI
- decreased uterus weight / MGI
- decreased seminal vesicle weight / MGI
- decreased thymus weight / MGI
- increased oxygen consumption / MGI
- head tossing / MGI
- decreased glycogen level / MGI
- decreased circulating glucose level / MGI
- decreased total body fat amount / MGI
STOCK Whrnwi/H
Status | Available to order |
EMMA ID | EM:01296 |
International strain name | STOCK Whrnwi/H |
Alternative name | wi |
Strain type | Spontaneous |
Allele/Transgene symbol | Whrnwi, |
Gene/Transgene symbol | Whrn |
Information from provider
Provider | Philomena Mburu |
Provider affiliation | MRC Mammalian Genetics Unit |
Phenotypic information | Homozygotes are deaf, show head tossing, circling and pale agouti colour. Heterozygotes and wild-type are both hearing and do not head toss or circle. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Usher syndrome type 2 / Orphanet_231178
MGI phenotypes (allele matching)
Literature references
- Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.;Mburu Philomena, Mustapha Mirna, Varela Anabel, Weil Dominique, El-Amraoui Aziz, Holme Ralph H, Rump Andreas, Hardisty Rachel E, Blanchard Stéphane, Coimbra Roney S, Perfettini Isabelle, Parkinson Nick, Mallon Ann-Marie, Glenister Pete, Rogers Mike J, Paige Adam J, Moir Lee, Clay Jo, Rosenthal Andre, Liu Xue Zhong, Blanco Gonzalo, Steel Karen P, Petit Christine, Brown Steve D M, ;2003;Nature genetics;34;421-8; 12833159
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