STOCK Trp53tm1Brd Tg(Wap-HBx)1Gmn/Kctt

Status

Available to order

EMMA IDEM:01788
International strain nameSTOCK Trp53tm1Brd Tg(Wap-HBx)1Gmn/Kctt
Alternative nameWAP-HBX (WAP-HBX-p53 +/-)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTrp53tm1Brd,
Gene/Transgene symbolTrp53

Information from provider

ProviderAdolf Graessmann
Provider affiliationInstitut für Molekularbiologie und Biochemie
Genetic informationHepatitis B virus X protein (HBx) under transcription control of Wap (whey acidic protein) promoter. The WAP-HBX animals were crossed to Trp53 -/- knock-out mice (Donehower LA et al., 1992, PubMed ID: 1552940).
Phenotypic informationBreast cancer formation.
Breeding historyAnimals were generated in 1998, crossed to Trp53 -/- knock-out mice and continuously propagated. The transgene as well as the knock-out mutation are kept at heterozygous state.
References
  • HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53.;Klein Andreas, Guhl Eva, Tzeng Yin-Jeh, Fuhrhop Jutta, Levrero Massimo, Graessmann Monika, Graessmann Adolf, ;2003;Oncogene;22;2910-9; 12771941

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased tumor incidence / MGI
  • increased sarcoma incidence / MGI
  • increased carcinoma incidence / MGI
  • decreased neuron apoptosis / MGI
  • increased osteosarcoma incidence / MGI
  • increased lymphoma incidence / MGI
  • altered response to myocardial infarction / MGI
  • decreased sensitivity to induced morbidity/mortality / MGI
  • decreased tumor growth/size / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • increased T cell derived lymphoma incidence / MGI
  • premature death / MGI
  • increased hemangiosarcoma incidence / MGI
  • abnormal cell cycle checkpoint function / MGI
  • decreased apoptosis / MGI
  • increased cell proliferation / MGI
  • increased rhabdomyosarcoma incidence / MGI
  • abnormal cell cycle / MGI
  • decreased cellular sensitivity to gamma-irradiation / MGI
  • oxidative stress / MGI
  • abnormal thymus physiology / MGI
  • enhanced cellular glucose import / MGI
  • abnormal chromosome number / MGI
  • decreased cellular sensitivity to ionizing radiation / MGI
  • abnormal cell physiology / MGI
  • delayed cellular replicative senescence / MGI
  • decreased sensitivity to induced cell death / MGI
  • decreased thymocyte apoptosis / MGI
  • increased fibroblast proliferation / MGI
  • decreased leukocyte cell number / MGI
  • decreased bone marrow cell number / MGI
  • small testis / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • anemia / MGI
  • premature aging / MGI
  • abnormal spine curvature / MGI
  • decreased hematopoietic stem cell number / MGI
  • decreased neuronal precursor cell number / MGI
  • abnormal male germ cell apoptosis / MGI
  • increased enterocyte apoptosis / MGI

Literature references

  • HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53.;Klein Andreas, Guhl Eva, Tzeng Yin-Jeh, Fuhrhop Jutta, Levrero Massimo, Graessmann Monika, Graessmann Adolf, ;2003;Oncogene;22;2910-9; 12771941

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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