- increased tumor incidence / MGI
- increased sarcoma incidence / MGI
- increased carcinoma incidence / MGI
- decreased neuron apoptosis / MGI
- increased osteosarcoma incidence / MGI
- increased lymphoma incidence / MGI
- altered response to myocardial infarction / MGI
- decreased sensitivity to induced morbidity/mortality / MGI
- decreased tumor growth/size / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased T cell derived lymphoma incidence / MGI
- premature death / MGI
- increased hemangiosarcoma incidence / MGI
- abnormal cell cycle checkpoint function / MGI
- decreased apoptosis / MGI
- increased cell proliferation / MGI
- increased rhabdomyosarcoma incidence / MGI
- abnormal cell cycle / MGI
- decreased cellular sensitivity to gamma-irradiation / MGI
- oxidative stress / MGI
- abnormal thymus physiology / MGI
- enhanced cellular glucose import / MGI
- abnormal chromosome number / MGI
- decreased cellular sensitivity to ionizing radiation / MGI
- abnormal cell physiology / MGI
- delayed cellular replicative senescence / MGI
- decreased sensitivity to induced cell death / MGI
- decreased thymocyte apoptosis / MGI
- increased fibroblast proliferation / MGI
- decreased leukocyte cell number / MGI
- decreased bone marrow cell number / MGI
- small testis / MGI
- abnormal spermatogenesis / MGI
- decreased body weight / MGI
- decreased body size / MGI
- anemia / MGI
- premature aging / MGI
- abnormal spine curvature / MGI
- decreased hematopoietic stem cell number / MGI
- decreased neuronal precursor cell number / MGI
- abnormal male germ cell apoptosis / MGI
- increased enterocyte apoptosis / MGI
STOCK Trp53tm1Brd Tg(Wap-HBx)1Gmn/Kctt
Status | Available to order |
EMMA ID | EM:01788 |
International strain name | STOCK Trp53tm1Brd Tg(Wap-HBx)1Gmn/Kctt |
Alternative name | WAP-HBX (WAP-HBX-p53 +/-) |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Trp53tm1Brd, |
Gene/Transgene symbol | Trp53 |
Information from provider
Provider | Adolf Graessmann |
Provider affiliation | Institut für Molekularbiologie und Biochemie |
Genetic information | Hepatitis B virus X protein (HBx) under transcription control of Wap (whey acidic protein) promoter. The WAP-HBX animals were crossed to Trp53 -/- knock-out mice (Donehower LA et al., 1992, PubMed ID: 1552940). |
Phenotypic information | Breast cancer formation. |
Breeding history | Animals were generated in 1998, crossed to Trp53 -/- knock-out mice and continuously propagated. The transgene as well as the knock-out mutation are kept at heterozygous state. |
References |
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Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53.;Klein Andreas, Guhl Eva, Tzeng Yin-Jeh, Fuhrhop Jutta, Levrero Massimo, Graessmann Monika, Graessmann Adolf, ;2003;Oncogene;22;2910-9; 12771941
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