- shiny fur / MGI
- abnormal coat appearance / MGI
- abnormal hair growth / MGI
- abnormal hair shaft morphology / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- lethality throughout fetal growth and development, complete penetrance / MGI
- decreased circulating insulin level / MGI
- decreased insulin secretion / MGI
- impaired glucose tolerance / MGI
STOCK Sox4M91Ark Foxq1sa/+ +/H
Status | Available to order |
EMMA ID | EM:01859 |
International strain name | STOCK Sox4M91Ark Foxq1sa/+ +/H |
Alternative name | M91B |
Strain type | Induced Mutant Strains : Radiation-induced |
Allele/Transgene symbol | Foxq1sa, |
Gene/Transgene symbol | Foxq1 |
Information from provider
Provider | Ruth Arkell |
Provider affiliation | MRC Mammalian Genetics Unit |
Genetic information | Mutation occurring on mouse chromosome 13 (equivalent to human chromosome 6p21.3-23 and 6p25). |
Phenotypic information | Embryonic lethal - fully penetrant. Dies of heart defect at approx. 14.5 dpc. |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Coffin-Siris syndrome / Orphanet_1465
MGI phenotypes (allele matching)
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
- Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse.;Arkell R M, Cadman M, Marsland T, Southwell A, Thaung C, Davies J R, Clay T, Beechey C V, Evans E P, Strivens M A, Brown S D, Denny P, ;2001;Mammalian genome : official journal of the International Mammalian Genome Society;12;687-94; 11641716
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