STOCK Grm7Tg(SMN2)89Ahmb Smg6Tg(SMN1*delta5)1Pks Smn1tm1Msd/H

Status

Available to order

EMMA IDEM:02500
International strain nameSTOCK Grm7Tg(SMN2)89Ahmb Smg6Tg(SMN1*delta5)1Pks Smn1tm1Msd/H
Alternative nameSMN Delta 5 /SMN2 low
Strain typeTransgenic Strains
Allele/Transgene symbolGrm7Tg(SMN2)89Ahmb,
Gene/Transgene symbolGrm7

Information from provider

ProviderNicholas Parkinson
Provider affiliationUniversity of Oxford
Genetic informationThis strain represents the SMN-Delta 5 transgene (EMMA strain EM:02416) bred, as a heterozygote, onto the SMN2-low line (see Monani et al., Hum Mol Genet 9 3 2000) which contains a knockout allele of the endogenous Smn locus and is homozygous for the human SMN2 BAC transgenic.
Phenotypic informationRescues post-natal lethality of SMN2-low strain.
Breeding historyAnimals heterozygous for the SMN-Delta 5 transgene were bred onto the SMN2-low line.
References
  • The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy.;Monani U R, Sendtner M, Coovert D D, Parsons D W, Andreassi C, Le T T, Jablonka S, Schrank B, Rossoll W, Prior T W, Morris G E, Burghes A H, ;2000;Human molecular genetics;9;333-9; 10655541
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • embryonic lethality / MGI
  • hypoactivity / MGI
  • decreased vertical activity / MGI
  • nervous system phenotype / MGI
  • decreased grip strength / MGI
  • abnormal apoptosis / MGI
  • abnormal embryonic tissue morphology / MGI
  • absent blastocoele / MGI
  • embryonic growth retardation / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • decreased motor neuron number / MGI
  • decreased body size / MGI
  • abnormal gait / MGI
  • premature death / MGI
  • abnormal spine curvature / MGI
  • paraparesis / MGI

Literature references

  • The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy.;Monani U R, Sendtner M, Coovert D D, Parsons D W, Andreassi C, Le T T, Jablonka S, Schrank B, Rossoll W, Prior T W, Morris G E, Burghes A H, ;2000;Human molecular genetics;9;333-9; 10655541

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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