STOCK Smad2tm6(SMAD2)Rob/H
| Status | Available to order |
| EMMA ID | EM:02511 |
| International strain name | STOCK Smad2tm6(SMAD2)Rob/H |
| Alternative name | Smad2 SF |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Smad2tm6(SMAD2)Rob, |
| Gene/Transgene symbol | Smad2 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | Knock-in allele at exon 1 of the Smad2 locus of an epitope-tagged (FLAG) human cDNA encoding short isoform of Smad2. Of use in evaluating Smad2-interacting partners in vivo and studies of TGFb signalling in vivo. |
| Phenotypic information | Homozygous lethal at 8.5 dpc. |
| Breeding history | Backcrossed to 129/SvEv |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial thoracic aortic aneurysm and aortic dissection / Orphanet_91387