STOCK Dnah11iv/H

Status

Available to order

EMMA IDEM:02531
International strain nameSTOCK Dnah11iv/H
Alternative nameiv
Strain typeSpontaneous
Allele/Transgene symbolDnah11iv,
Gene/Transgene symbolDnah11

Information from provider

ProviderKatharine Hummel
Provider affiliationMedical Research Council
Additional ownerFor further information contact Martin Fray, FESA Manager. m.fray@har.mrc.ac.uk
Genetic informationHomozygotes have randomised situs (sidedness).
Phenotypic information50% of homozygotes have situs inversus totalis.
Breeding historyComplex mixed background; inbred over more than 20 generations.
References
  • Situs Viscerum Inversus;Hummel KP, Chapman D;1959;Mouse News Lett.;14;21; 9353118
  • Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.;Supp D M, Witte D P, Potter S S, Brueckner M, ;1997;Nature;389;963-6;
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • right pulmonary isomerism / MGI
  • abnormal autopod morphology / MGI
  • abnormal liver morphology / MGI
  • abnormal spleen morphology / MGI
  • abnormal embryo implantation / MGI
  • reduced fertility / MGI
  • abnormal cardiovascular system morphology / MGI
  • situs inversus / MGI
  • abnormal heart atrium morphology / MGI
  • left pulmonary isomerism / MGI
  • right atrial isomerism / MGI
  • abnormal inferior vena cava morphology / MGI
  • left atrial isomerism / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • abnormal heart atrium auricular region morphology / MGI
  • abnormal hepatic portal vein morphology / MGI
  • abnormal motile primary cilium morphology / MGI
  • heterotaxia / MGI
  • absent nodal flow / MGI

Literature references

  • Situs Viscerum Inversus;Hummel KP, Chapman D;1959;Mouse News Lett.;14;21; 9353118
  • Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice.;Supp D M, Witte D P, Potter S S, Brueckner M, ;1997;Nature;389;963-6;

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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