| Status | Available to order |
| EMMA ID | EM:04338 |
| International strain name | STOCK Prnptm1Cwe Tg(Prnp/PRNP*ARR)FM16Pcg/H |
| Alternative name | Tg(OvPrP)FM16 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prnptm1Cwe, |
| Gene/Transgene symbol | Prnp |
| Provider | Peter Griffiths |
| Provider affiliation | Department of Pathology and Host Susceptibility, Animal Health and Veterinary Laboratories Agency (AHVLA) |
| Genetic information | A ~12 kb transgene, comprised of chimaeric DNA sequence encoding a sheep PrP (ARR allele) coding region and mouse PrP gene promoter and 3'-UTR, was used to microinject pronuclear stage FVB/N fertilised oocytes. |
| Phenotypic information | Overexpression of transgenic ovine PrPC in brain and other tissues in order to confer increased susceptibility to TSE diseases compared to wild-type mice. |
| Breeding history | Bred to 9 generations by crossing with PrP null (Zurich I) mice. Maintained as a transgene heterozygous line. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous 0, heterozygous 0 |
| Breeding at archiving centre | No breeding was performed at the archiving centre. |
| Stage of embryos | 8-cell |
Orphanet associated rare diseases, based on orthologous gene matching
