- absent coat pigmentation / MGI
- diluted coat color / MGI
- abnormal coat/hair pigmentation / MGI
- absent eye pigmentation / MGI
- abnormal coat appearance / MGI
- decreased eye pigmentation / MGI
- mottled coat / MGI
- abnormal eye pigmentation / MGI
- belly spot / MGI
- hypopigmentation / MGI
- variegated eye pigmentation pattern / MGI
- decreased ear pigmentation / MGI
STOCK Tyrc/Tyrc-32DSD/Cnbc
Status | Available to order |
EMMA ID | EM:04767 |
International strain name | STOCK Tyrc/Tyrc-32DSD/Cnbc |
Alternative name | albino Tyr |
Strain type | Spontaneous |
Allele/Transgene symbol | Tyrc, |
Gene/Transgene symbol | Tyr |
Information from provider
Provider | Sarah Shinpock |
Provider affiliation | Biology Division, Oak Ridge National Laboratory |
Additional owner | Eugene N. Rinchik, ORNL, Oak Ridge TN, U.S.A |
Genetic information | Radiation-induced mutation that carries a large (a few hundred kilobases) intrachromosomal deletion, involving the entire tyrosinase locus, obtained from Eugene N Rinchik in 2000, through Sarah G Shinpock, at ORNL, Oak Ridge, Tennessee, and, since then, bred to Hsd:NMRI at CNB. |
Phenotypic information | Albino phenotype. |
Breeding history | Obtained in 2000 from ORNL, and bred, since then, to albino outbred Hsd:NMRI mice, eventually maintained as homozygous mutants. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | homozygous NMRI, wild-type NMRI |
Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Temperature-sensitive oculocutaneous albinism type 1 / Orphanet_352737
- Oculocutaneous albinism type 1A / Orphanet_79431
- Oculocutaneous albinism type 1B / Orphanet_79434
- Minimal pigment oculocutaneous albinism type 1 / Orphanet_352734
- Ocular albinism with congenital sensorineural deafness / Orphanet_352740
MGI phenotypes (allele matching)
Literature references
- A strategy to study tyrosinase transgenes in mouse melanocytes.;Lavado Alfonso, Matheu Ander, Serrano Manuel, Montoliu Lluís, ;2005;BMC cell biology;6;18; 15826307
- Molecular analysis of viable spontaneous and radiation-induced albino (c)-locus mutations in the mouse.;Rinchik E M, Stoye J P, Frankel W N, Coffin J, Kwon B S, Russell L B, ;1993;Mutation research;286;199-207; 7681531
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