STOCK Tyrc/Tyrc-32DSD/Cnbc

Status

Available to order

EMMA IDEM:04767
International strain nameSTOCK Tyrc/Tyrc-32DSD/Cnbc
Alternative namealbino Tyr NMR/Hsd
Strain typeSpontaneous
Allele/Transgene symbolTyrc,
Gene/Transgene symbolTyr

Information from provider

ProviderSarah Shinpock
Provider affiliationBiology Division, Oak Ridge National Laboratory
Additional ownerEugene N. Rinchik, ORNL, Oak Ridge TN, U.S.A
Genetic informationRadiation-induced mutation that carries a large (a few hundred kilobases) intrachromosomal deletion, involving the entire tyrosinase locus, obtained from Eugene N Rinchik in 2000, through Sarah G Shinpock, at ORNL, Oak Ridge, Tennessee, and, since then, bred to Hsd:NMRI at CNB.
Phenotypic informationAlbino phenotype.
Breeding historyObtained in 2000 from ORNL, and bred, since then, to albino outbred Hsd:NMRI mice, eventually maintained as homozygous mutants.
References
  • A strategy to study tyrosinase transgenes in mouse melanocytes.;Lavado Alfonso, Matheu Ander, Serrano Manuel, Montoliu Lluís, ;2005;BMC cell biology;6;18; 15826307
  • Molecular analysis of viable spontaneous and radiation-induced albino (c)-locus mutations in the mouse.;Rinchik E M, Stoye J P, Frankel W N, Coffin J, Kwon B S, Russell L B, ;1993;Mutation research;286;199-207; 7681531
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous NMRI, wild-type NMRI
Stage of embryos8-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • absent coat pigmentation / MGI
  • diluted coat color / MGI
  • abnormal coat/hair pigmentation / MGI
  • absent eye pigmentation / MGI
  • abnormal coat appearance / MGI
  • decreased eye pigmentation / MGI
  • mottled coat / MGI
  • abnormal eye pigmentation / MGI
  • belly spot / MGI
  • hypopigmentation / MGI
  • variegated eye pigmentation pattern / MGI
  • decreased ear pigmentation / MGI

Literature references

  • A strategy to study tyrosinase transgenes in mouse melanocytes.;Lavado Alfonso, Matheu Ander, Serrano Manuel, Montoliu Lluís, ;2005;BMC cell biology;6;18; 15826307
  • Molecular analysis of viable spontaneous and radiation-induced albino (c)-locus mutations in the mouse.;Rinchik E M, Stoye J P, Frankel W N, Coffin J, Kwon B S, Russell L B, ;1993;Mutation research;286;199-207; 7681531

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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