MSOFAST/Orl
Status | Available to order |
EMMA ID | EM:04844 |
International strain name | MSOFAST/Orl |
Alternative name | MSO-Fast |
Strain type | Spontaneous |
Allele/Transgene symbol | MSO-Fast |
Gene/Transgene symbol | MSO-Fast |
Information from provider
Provider | Jean-François Cloix |
Provider affiliation | Neurobiology Laboratory, University of Orleans |
Genetic information | Genetic selection of MSO-Fast mice based upon their short latency toward seizures induced by injection of a single dose of 75 mg/kg methionine sulfoximine. The selection was performed on genetic random crosses of eight inbred mouse strains: ABP/Le, A/J, BALB/c, C3H/HeJ, C57BL/6J, CBA/H, DBA/2J and SWXL-4. |
Phenotypic information | MSO-Fast line is characterized by 1) a short latency and a high susceptibility toward seizures upon injection of methionine sulfoximine; 2) susceptibility to kainic acid and MK-801; 3) no increase in brain glycogen content induced by methionine sulfoximine; 4) involvement of 5-HT in seizures and brain glycogen content. This line has its counterpart as the MSO-Slow mice. |
Breeding history | Random crosses of eight inbred mouse strains: ABP/Le, A/J, BALB/c, C3H/HeJ, C57BL/6J, CBA/H, DBA/2J and SWXL-4 to generate G1. G1 was challenged by a single ip injection of 75 mg/kg methionine sulfoximine and selected upon latency methionine sulfoximine induced seizures. Mice having the shortest latency were inter-crossed without brother-sister crosses. This challenge was repeated for 10 generations, reaching the point where the phenotype was considered as fixed. Then crossing sisters with brothers for 9 generations to perform inbreeding. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous 0, homozygous 0 |
Breeding at archiving centre | Strain with no genotyping |
Literature references
- Selection of two lines of mice based on latency to onset of methionine sulfoximine seizures.;Cloix Jean-François, Tahi Zahir, Martin Benoît, Hévor Tobias, ;2010;Epilepsia;51;118-28; 20015245
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