- increased tumor incidence / MGI
- thymus hyperplasia / MGI
- increased sarcoma incidence / MGI
- increased osteosarcoma incidence / MGI
- increased incidence of tumors by chemical induction / MGI
- increased thymus weight / MGI
- increased double-positive T cell number / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased small lymphocytic lymphoma incidence / MGI
- increased splenocyte proliferation / MGI
- increased lymphoma incidence / MGI
STOCK Cdkn2atm2.1Rdp Tg(Cnp-TVA,-lacZ)B8Ubc/Kctt
Status | Available to order |
EMMA ID | EM:04995 |
International strain name | STOCK Cdkn2atm2.1Rdp Tg(Cnp-TVA,-lacZ)B8Ubc/Kctt |
Alternative name | Ctv-a INK4a-/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cdkn2atm2.1Rdp, |
Gene/Transgene symbol | Cdkn2a |
Information from provider
Provider | Lene Uhrbom |
Provider affiliation | Department of Neuroscience, Uppsala University |
Additional owner | Lene Uhrbom, Uppsala University, Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden |
Genetic information | Transgenic construct: pCNPase-TV-A-IRES-lacZ made in FVB/N. Crossed with strain containing targeted deletion p16INK4a (exon 1a of the cyclin-dependent kinase inhibitor 2A gene). |
Phenotypic information | Allows for infection of 2',3'-cyclic nucleotide 3' phosphodiesterase (CNPase)-expressing cells by RCAS virus. The deletion of exon 1a in the cyclin-dependent kinase inhibitor 2A gene results in complete loss of p16INK4a transcription but not p19ARF. |
Breeding history | The TV-A founder mouse was crossed with FVB/N and subsequently intercrossed to establish homozygotes. Following, TVA-A transgenic mice were crossed with p16INK4a null mice and subsequently F1 progeny were crossed to generate mice homozygous for TV-A and p16INK4a deletion. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Animals used for archiving | heterozygous 0, wild-type FVB/N |
Breeding at archiving centre | No breeding at Karolinska Inst. |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Oligodendrocyte progenitor cells can act as cell of origin for experimental glioma.;Lindberg N, Kastemar M, Olofsson T, Smits A, Uhrbom L, ;2009;Oncogene;28;2266-75; 19421151
- Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis.;Sharpless N E, Bardeesy N, Lee K H, Carrasco D, Castrillon D H, Aguirre A J, Wu E A, Horner J W, DePinho R A, ;2001;Nature;413;86-91; 11544531
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