C57BL/6N-Tnfsf13btm1.1Arte/Ieg
Status | Available to order |
EMMA ID | EM:05501 |
International strain name | C57BL/6N-Tnfsf13btm1.1Arte/Ieg |
Alternative name | TNFSF13b KO cond |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Tnfsf13btm1.1 |
Gene/Transgene symbol | Tnfsf13b |
Information from provider
Provider | Helmholtz Zentrum Muenchen |
Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen German Research Center for Environmental Health (GmbH) |
Genetic information | The mouse Tnfsf13b ORF is encoded by exons 1-7, with the TNF domain encoded by exons 4-7, while mouse exon 3 is not present in the human orthologue. Exons 5-6 have been flanked by loxP sites, as their genetic ablation should result in loss of function by deletion of more than 60% of the TNF domain. The conditional targeted mutation has been obtained by in vivo, Flp recombinase-mediated removal of the neomycin selection marker. |
Phenotypic information | TO BE PROVIDED |
Breeding history | Targeting performed in C57BL/6N ES cells and confirmed by Southern blotting. Crossed to C57BL/6N-Tg(CAG-flpe)2Arte mice to obtain mutant founders with excised neo cassette. Maintained on C57BL/6N background. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Animals used for archiving | heterozygous C57BL/6NTac, wild-type C57BL/6N |
Stage of embryos | 2-cell |
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