STOCK Otx2tm6Asim/Cnrm
| Status | Available to order |
| EMMA ID | EM:05626 |
| International strain name | STOCK Otx2tm6Asim/Cnrm |
| Alternative name | Otx2-Flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Otx2tm6Asim, |
| Gene/Transgene symbol | Otx2 |
Information from provider
| Provider | Antonio Simeone |
| Provider affiliation | Ceinge Biotecnologie Avanzate |
| Genetic information | The exon 2 of Otx2 gene is flanked by loxP sites. |
| Phenotypic information | No phenotype. Homozygous mice are normal in size and fertile. |
| Breeding history | Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined pituitary hormone deficiencies, genetic forms / Orphanet_95494
- Butterfly-shaped pigment dystrophy / Orphanet_99001
- Colobomatous microphthalmia / Orphanet_98938
- Nanophthalmos / Orphanet_35612
- Syndromic microphthalmia type 5 / Orphanet_178364
- Septo-optic dysplasia spectrum / Orphanet_3157
Literature references
- Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.;Puelles Eduardo, Acampora Dario, Lacroix Emmanuel, Signore Massimo, Annino Alessandro, Tuorto Francesca, Filosa Stefania, Corte Giorgio, Wurst Wolfgang, Ang Siew-Lan, Simeone Antonio, ;2003;Nature neuroscience;6;453-60; 12652306