MGI phenotypes (allele matching)
- prenatal lethality, complete penetrance / MGI
STOCK Map3k7tm1.2Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:08428 |
| International strain name | STOCK Map3k7tm1.2Gkl/Flmg |
| Alternative name | TAK1delta/+ [B6-Map3k7tm1.2Gkl/Flmg] |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Map3k7tm1.2Gkl, |
| Gene/Transgene symbol | Map3k7 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | Immunology, BSRC Al. Fleming |
| Genetic information | Upon cre-mediated recombination exon 2 was removed, encoding a kinase-dead truncated form of TAK1. |
| Phenotypic information | Homozygous:No overt phenotype.Heterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cardiospondylocarpofacial syndrome / Orphanet_3238
- Frontometaphyseal dysplasia / Orphanet_1826
Literature references
- Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.;Eftychi Christina, Karagianni Niki, Alexiou Maria, Apostolaki Maria, Kollias George, ;2012;PloS one;7;e31550; 22348103