STOCK Prdm6tm1.1Jrld/Biat
| Status | Available to order |
| EMMA ID | EM:08437 |
| International strain name | STOCK Prdm6tm1.1Jrld/Biat |
| Alternative name | B6.129Ola-Prdm6 tm1Gew |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Prdm6tm1.1Jrld, |
| Gene/Transgene symbol | Prdm6 |
Information from provider
| Provider | Andreas Gewies |
| Provider affiliation | Institute of Clinical Chemistry and Pathobiology, Technical University of Munich - Medical School |
| Genetic information | Exon 3 of the Prdm6 gene according to ENSEMBL entry ENSMUSG00000069378 was flanked by loxP sites via homologous recombination in E14TG2a.4 murine embryonic stem cells. The neomycin selection cassette was removed using flp deleter mice to obtain the floxed Prdm6 allele. |
| Phenotypic information | Homozygous:Homozygous Prdm6 floxed/floxed mice are viable, healthy and fertile and can be crossed to cell-type specific Cre deleter strains. Homozygous germline deletion of exon 3 (Prdm6 -/-) results in lethality around 11 dpc during embryonic development.Heterozygous:Heterozygous Prdm6 +/- knockout mice are viable, healthy and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial patent arterial duct / Orphanet_466729
Literature references
- Prdm6 is essential for cardiovascular development in vivo.;Gewies Andreas, Castineiras-Vilarino Mercedes, Ferch Uta, Jährling Nina, Heinrich Katja, Hoeckendorf Ulrike, Przemeck Gerhard K H, Munding Matthias, Groß Olaf, Schroeder Timm, Horsch Marion, Karran E Loraine, Majid Aneela, Antonowicz Stefan, Beckers Johannes, Hrabé de Angelis Martin, Dodt Hans-Ulrich, Peschel Christian, Förster Irmgard, Dyer Martin J S, Ruland Jürgen, ;2013;PloS one;8;e81833; 24278461