STOCK Tg(Ttr-SMYD3)1Ital/Flmg
| Status | Available to order |
| EMMA ID | EM:09494 |
| International strain name | STOCK Tg(Ttr-SMYD3)1Ital/Flmg |
| Alternative name | B6.CBA-Tg(Ttr-SMYD3)1Ital/Flmg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Ttr-SMYD3)1Ital |
| Gene/Transgene symbol | Tg(Ttr-SMYD3)1Ital |
Information from provider
| Provider | Iannis Talianidis |
| Provider affiliation | BSRC Alexander Fleming |
| Genetic information | The transgene contains the mouse Ttr promoter, expressing the human SMYD3 gene. Three hemagglutinin (HA) tags and three FLAG tags were inserted at the C- and N-terminus of the SMYD3 gene respectively. Hepatic expression of this transgene is at least 15-fold above endogenous levels. |
| Phenotypic information | Homozygous:Mice are phenotypically normal and viable. Livers are visibly and microscopically normal. In some rare cases, livers of aged mice are pale in color and when examined histologically fatty liver features are observed.Heterozygous:Same as homozygous. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous C57BL/6.CBA, wild-type (C57BL/6 x CBA)F1 |
| Stage of embryos | Morula |
Literature references
- Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.;Sarris Michalis E, Moulos Panagiotis, Haroniti Anna, Giakountis Antonis, Talianidis Iannis, ;2016;Cancer cell;29;354-366; 26908355