STOCK Dll1tm8.1Gos/Kctt

Status

Available to order

EMMA IDEM:10370
International strain nameSTOCK Dll1tm8.1Gos/Kctt
Alternative nameDll1EGF8m
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolDll1tm8.1Gos
Gene/Transgene symbolDll1

Information from provider

ProviderAchim Gossler
Provider affiliationMedizinische Hochschule Hannover
Genetic informationKnock in of a Dll1 mini gene with mutated EGF8 into the Dll1 locus.
Phenotypic informationHomozygous:
EGF8m lethal massive skeletal defects.

Heterozygous:
all alleles are heterozygous normal
Breeding historyFrom isogenic 129ImJ three generations on CD1, then kept on this mixed background.
References
  • Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.;Schuster-Gossler Karin, Cordes Ralf, Müller Julia, Geffers Insa, Delany-Heiken Patricia, Taft Manuel, Preller Matthias, Gossler Achim, ;2016;Genetics;202;1119-33; 26801181
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Animals used for archivingheterozygous 0

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • increased monocyte cell number / IMPC
  • abnormal whole-body plethysmography / IMPC
  • decreased tidal volume / IMPC
  • abnormal behavior / IMPC
  • increased blood urea nitrogen level / IMPC
  • decreased body weight / IMPC
  • increased hemoglobin content / IMPC
  • decreased circulating calcium level / IMPC
  • decreased body temperature / IMPC
  • decreased circulating cholesterol level / IMPC
  • thrombocytopenia / IMPC
  • decreased circulating triglyceride level / IMPC
  • abnormal anxiety-related response / IMPC
  • decreased mean platelet volume / IMPC
  • decreased circulating glucose level / IMPC
  • decreased vertical activity / IMPC
  • increased leukocyte cell number / IMPC
  • decreased circulating potassium level / IMPC
  • hyperactivity / IMPC
  • decreased defecation amount / IMPC
  • decreased circulating sodium level / IMPC
  • increased lymphocyte cell number / IMPC
  • increased grip strength / IMPC
  • abnormal righting response / IMPC
  • decreased circulating chloride level / IMPC
  • increased granulocyte number / IMPC
  • abnormal eye electrophysiology / IMPC
MGI phenotypes (gene matching)
  • increased bone mineral density / MGI
  • decreased bone mineral density / MGI
  • abnormal vertebrae morphology / MGI
  • abnormal heart morphology / MGI
  • short tail / MGI
  • abnormal myogenesis / MGI
  • abnormal brain development / MGI
  • fused dorsal root ganglion / MGI
  • abnormal spinal nerve morphology / MGI
  • decreased body height / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • hyperactivity / MGI
  • hypoactivity / MGI
  • no spontaneous movement / MGI
  • abnormal blood vessel morphology / MGI
  • abnormal somite development / MGI
  • incomplete somite formation / MGI
  • abnormal somite shape / MGI
  • decreased IgA level / MGI
  • hemorrhage / MGI
  • perinatal lethality / MGI
  • premature death / MGI
  • abnormal muscle morphology / MGI
  • abnormal axial skeleton morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased circulating triglyceride level / MGI
  • abnormal somatic nervous system morphology / MGI
  • situs inversus / MGI
  • abnormal notochord morphology / MGI
  • nervous system phenotype / MGI
  • abnormal defecation / MGI
  • abnormal pancreas development / MGI
  • increased lean body mass / MGI
  • decreased lean body mass / MGI
  • abnormal primitive node morphology / MGI
  • caudal body truncation / MGI
  • absent embryonic cilia / MGI
  • abnormal direction of embryo turning / MGI
  • abnormal direction of heart looping / MGI
  • decreased lumbar vertebrae number / MGI
  • decreased skeletal muscle mass / MGI
  • increased mean systemic arterial blood pressure / MGI
  • decreased B-1 B cell number / MGI
  • decreased neuronal precursor cell number / MGI
  • increased B cell number / MGI
  • decreased circulating cholesterol level / MGI
  • increased motor neuron number / MGI
  • decreased heart rate / MGI
  • muscle phenotype / MGI
  • embryo phenotype / MGI
  • immune system phenotype / MGI
  • decreased circulating total protein level / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • artery stenosis / MGI
  • increased systemic arterial diastolic blood pressure / MGI
  • increased systemic arterial systolic blood pressure / MGI
  • abnormal paraxial mesoderm morphology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • increased blood uric acid level / MGI
  • decreased blood uric acid level / MGI
  • increased neuron number / MGI
  • increased basal metabolism / MGI
  • abnormal neuron differentiation / MGI
  • decreased total body fat amount / MGI
  • abnormal bone mineral density / MGI
  • increased susceptibility to weight loss / MGI
  • aorta stenosis / MGI
  • abnormal Q wave / MGI
  • perinatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • decreased food intake / MGI
  • enlarged floor plate / MGI
  • abnormal somite border morphology / MGI
  • decreased basal metabolism / MGI

Literature references

  • Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.;Schuster-Gossler Karin, Cordes Ralf, Müller Julia, Geffers Insa, Delany-Heiken Patricia, Taft Manuel, Preller Matthias, Gossler Achim, ;2016;Genetics;202;1119-33; 26801181

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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