- increased monocyte cell number / IMPC
- abnormal whole-body plethysmography / IMPC
- decreased tidal volume / IMPC
- abnormal behavior / IMPC
- increased blood urea nitrogen level / IMPC
- decreased body weight / IMPC
- increased hemoglobin content / IMPC
- decreased circulating calcium level / IMPC
- decreased body temperature / IMPC
- decreased circulating cholesterol level / IMPC
- thrombocytopenia / IMPC
- decreased circulating triglyceride level / IMPC
- abnormal anxiety-related response / IMPC
- decreased mean platelet volume / IMPC
- decreased circulating glucose level / IMPC
- decreased vertical activity / IMPC
- increased leukocyte cell number / IMPC
- decreased circulating potassium level / IMPC
- hyperactivity / IMPC
- decreased defecation amount / IMPC
- decreased circulating sodium level / IMPC
- increased lymphocyte cell number / IMPC
- increased grip strength / IMPC
- abnormal righting response / IMPC
- decreased circulating chloride level / IMPC
- increased granulocyte number / IMPC
- abnormal eye electrophysiology / IMPC
STOCK Dll1tm8.1Gos/Kctt
Status | Available to order |
EMMA ID | EM:10370 |
International strain name | STOCK Dll1tm8.1Gos/Kctt |
Alternative name | Dll1EGF8m |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Dll1tm8.1Gos |
Gene/Transgene symbol | Dll1 |
Information from provider
Provider | Achim Gossler |
Provider affiliation | Medizinische Hochschule Hannover |
Genetic information | Knock in of a Dll1 mini gene with mutated EGF8 into the Dll1 locus. |
Phenotypic information | Homozygous:EGF8m lethal massive skeletal defects.Heterozygous:all alleles are heterozygous normal |
Breeding history | From isogenic 129ImJ three generations on CD1, then kept on this mixed background. |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Animals used for archiving | heterozygous 0 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Alobar holoprosencephaly / Orphanet_93925
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469
- Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
- Microform holoprosencephaly / Orphanet_280200
- Septopreoptic holoprosencephaly / Orphanet_280195
- Semilobar holoprosencephaly / Orphanet_220386
- Lobar holoprosencephaly / Orphanet_93924
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- decreased bone mineral density / MGI
- abnormal vertebrae morphology / MGI
- abnormal heart morphology / MGI
- short tail / MGI
- abnormal myogenesis / MGI
- abnormal brain development / MGI
- fused dorsal root ganglion / MGI
- abnormal spinal nerve morphology / MGI
- decreased body height / MGI
- decreased body length / MGI
- decreased body weight / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- no spontaneous movement / MGI
- abnormal blood vessel morphology / MGI
- abnormal somite development / MGI
- incomplete somite formation / MGI
- abnormal somite shape / MGI
- decreased IgA level / MGI
- hemorrhage / MGI
- perinatal lethality / MGI
- premature death / MGI
- abnormal muscle morphology / MGI
- abnormal axial skeleton morphology / MGI
- abnormal neural tube morphology / MGI
- no abnormal phenotype detected / MGI
- decreased circulating triglyceride level / MGI
- abnormal somatic nervous system morphology / MGI
- situs inversus / MGI
- abnormal notochord morphology / MGI
- nervous system phenotype / MGI
- abnormal defecation / MGI
- abnormal pancreas development / MGI
- increased lean body mass / MGI
- decreased lean body mass / MGI
- abnormal primitive node morphology / MGI
- caudal body truncation / MGI
- absent embryonic cilia / MGI
- abnormal direction of embryo turning / MGI
- abnormal direction of heart looping / MGI
- decreased lumbar vertebrae number / MGI
- decreased skeletal muscle mass / MGI
- increased mean systemic arterial blood pressure / MGI
- decreased B-1 B cell number / MGI
- decreased neuronal precursor cell number / MGI
- increased B cell number / MGI
- decreased circulating cholesterol level / MGI
- increased motor neuron number / MGI
- decreased heart rate / MGI
- muscle phenotype / MGI
- embryo phenotype / MGI
- immune system phenotype / MGI
- decreased circulating total protein level / MGI
- abnormal enzyme/coenzyme activity / MGI
- artery stenosis / MGI
- increased systemic arterial diastolic blood pressure / MGI
- increased systemic arterial systolic blood pressure / MGI
- abnormal paraxial mesoderm morphology / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG1 level / MGI
- decreased IgG2b level / MGI
- decreased IgG3 level / MGI
- increased blood uric acid level / MGI
- decreased blood uric acid level / MGI
- increased neuron number / MGI
- increased basal metabolism / MGI
- abnormal neuron differentiation / MGI
- decreased total body fat amount / MGI
- abnormal bone mineral density / MGI
- increased susceptibility to weight loss / MGI
- aorta stenosis / MGI
- abnormal Q wave / MGI
- perinatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
- decreased food intake / MGI
- enlarged floor plate / MGI
- abnormal somite border morphology / MGI
- decreased basal metabolism / MGI
Literature references
- Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.;Schuster-Gossler Karin, Cordes Ralf, Müller Julia, Geffers Insa, Delany-Heiken Patricia, Taft Manuel, Preller Matthias, Gossler Achim, ;2016;Genetics;202;1119-33; 26801181
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