- short tail / MGI
- decreased vertebrae number / MGI
- truncated notochord / MGI
- postnatal lethality / MGI
- abnormal primitive node morphology / MGI
- abnormal motile primary cilium morphology / MGI
- decreased embryonic cilium length / MGI
- abnormal embryonic cilium location or orientation / MGI
- absent nodal flow / MGI
STOCK Nototm1Gos/Kctt
Status | Available to order |
EMMA ID | EM:10371 |
International strain name | STOCK Nototm1Gos/Kctt |
Alternative name | Nototm1Gos |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Nototm1Gos, |
Gene/Transgene symbol | Noto |
Information from provider
Provider | Achim Gossler |
Provider affiliation | Medizinische Hochschule Hannover |
Genetic information | Knock-in of GFP into the Noto locus. |
Phenotypic information | Homozygous:Disruption of l- r- asymmetry of visceral organs.Heterozygous:none |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Animals used for archiving | heterozygous mixed |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.;Abdelkhalek Hanaa Ben, Beckers Anja, Schuster-Gossler Karin, Pavlova Maria N, Burkhardt Hannelore, Lickert Heiko, Rossant Janet, Reinhardt Richard, Schalkwyk Leonard C, Müller Ines, Herrmann Bernhard G, Ceolin Marcelo, Rivera-Pomar Rolando, Gossler Achim, ;2004;Genes & development;18;1725-36; 15231714
- The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.;Beckers Anja, Alten Leonie, Viebahn Christoph, Andre Philipp, Gossler Achim, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;15765-70; 17884984
- Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.;Alten Leonie, Schuster-Gossler Karin, Beckers Anja, Groos Stephanie, Ulmer Bärbel, Hegermann Jan, Ochs Matthias, Gossler Achim, ;2012;Development (Cambridge, England);139;1276-84; 22357932
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