STOCK Nototm1Gos/Kctt

Status

Available to order

EMMA IDEM:10371
International strain nameSTOCK Nototm1Gos/Kctt
Alternative nameNototm1Gos
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolNototm1Gos,
Gene/Transgene symbolNoto

Information from provider

ProviderAchim Gossler
Provider affiliationMedizinische Hochschule Hannover
Genetic informationKnock-in of GFP into the Noto locus.
Phenotypic informationHomozygous:
Disruption of l- r- asymmetry of visceral organs.

Heterozygous:
none
References
  • The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.;Abdelkhalek Hanaa Ben, Beckers Anja, Schuster-Gossler Karin, Pavlova Maria N, Burkhardt Hannelore, Lickert Heiko, Rossant Janet, Reinhardt Richard, Schalkwyk Leonard C, Müller Ines, Herrmann Bernhard G, Ceolin Marcelo, Rivera-Pomar Rolando, Gossler Achim, ;2004;Genes & development;18;1725-36; 15231714
  • The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.;Beckers Anja, Alten Leonie, Viebahn Christoph, Andre Philipp, Gossler Achim, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;15765-70; 17884984
  • Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.;Alten Leonie, Schuster-Gossler Karin, Beckers Anja, Groos Stephanie, Ulmer Bärbel, Hegermann Jan, Ochs Matthias, Gossler Achim, ;2012;Development (Cambridge, England);139;1276-84; 22357932
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Animals used for archivingheterozygous mixed

Disease and phenotype information

MGI phenotypes (allele matching)
  • short tail / MGI
  • decreased vertebrae number / MGI
  • truncated notochord / MGI
  • postnatal lethality / MGI
  • abnormal primitive node morphology / MGI
  • abnormal motile primary cilium morphology / MGI
  • decreased embryonic cilium length / MGI
  • abnormal embryonic cilium location or orientation / MGI
  • absent nodal flow / MGI

Literature references

  • The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.;Abdelkhalek Hanaa Ben, Beckers Anja, Schuster-Gossler Karin, Pavlova Maria N, Burkhardt Hannelore, Lickert Heiko, Rossant Janet, Reinhardt Richard, Schalkwyk Leonard C, Müller Ines, Herrmann Bernhard G, Ceolin Marcelo, Rivera-Pomar Rolando, Gossler Achim, ;2004;Genes & development;18;1725-36; 15231714
  • The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.;Beckers Anja, Alten Leonie, Viebahn Christoph, Andre Philipp, Gossler Achim, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;15765-70; 17884984
  • Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.;Alten Leonie, Schuster-Gossler Karin, Beckers Anja, Groos Stephanie, Ulmer Bärbel, Hegermann Jan, Ochs Matthias, Gossler Achim, ;2012;Development (Cambridge, England);139;1276-84; 22357932

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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