STOCK Nanogtm1.1Asim/Cnrm
| Status | Available to order |
| EMMA ID | EM:11120 |
| International strain name | STOCK Nanogtm1.1Asim/Cnrm |
| Alternative name | Nanog deltaOBS5 |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Nanogtm1.1Asim, |
| Gene/Transgene symbol | Nanog |
Information from provider
| Provider | Antonio Simeone |
| Provider affiliation | IGB-CNR |
| Genetic information | Mutagenesis of Otx2 binding site on Nanog promoter at -144 respect to methionine 1. |
| Phenotypic information | Homozygous:Mice are viable and fertile, but, compared to wild-type, the number of mice per litter was reduced by about 50%. This reduction was also observed at E12.5 and E6.5.Heterozygous:Mice are viable and fertile |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.;Acampora Dario, Omodei Daniela, Petrosino Giuseppe, Garofalo Arcomaria, Savarese Marco, Nigro Vincenzo, Di Giovannantonio Luca Giovanni, Mercadante Vincenzo, Simeone Antonio, ;2016;Cell reports;15;2651-64; 27292645