The Animal Modelling Facility (AMF) at the Netherlands Cancer Institute (NKI) consists of a molecular biology laboratory, an embryo manipulation laboratory and 2 rooms in the Animal Facility.
The AMF provides all services related to the generation of genetically engineered mice (GEM) for academic researchers, with full-service covering the design and all hands-on steps. The AMF keeps track of recent technological developments and tests their usefulness for improving model generation.
For each GEM the AMF designs efficient genotyping protocols. In addition, for each GEM the AMF provides cryopreservation and if needed revitalisation.
The AMF provides the services of modulating ES-cells for in vitro studies and produce viruses for somatic modelling.
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Gulen MF, Samson N, Keller A, et al. cGAS-STING drives ageing-related inflammation and neurodegeneration. Nature. 2023; 620(7973):374-380 doi.org/10.1038/s41586-023-06373-1
Morgner J, Bornes L, Hahn K, et al. A Lamb1Dendra2 mouse model identifies basement-membrane-producing origins and dynamics in PyMT breast tumors. Dev Cell. 2023;58(7):535-549 doi.org/10.1016/j.devcel.2023.02.017
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