-
Ravindran A, Holappa L, Niskanen H, et al. Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis. Cardiovasc Res. 2024; 120(8):869-882. doi: 10.1093/cvr/cvae028.
-
Brouillard P, Murtomäki A, Leppänen VM, et al. Loss-of-function mutations of the TIE1 receptor tyrosine kinase cause late-onset primary lymphedema. J Clin Invest. 2024; 134(14):e173586. doi: 10.1172/JCI173586.
-
Kapiainen E, Elamaa H, Miinalainen I, et al. Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm’s Canal Maintenance. Invest Ophthalmol Vis Sci. 2022; 63(11):1. doi: 10.1167/iovs.63.11.1
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Hiltunen AE, Kangas SM, Ohlmeier S, et al. Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease. Mol Med. 2020; 26(1):123. doi: 10.1186/s10020-020-00245-4
1. CRISPR/Cas9 editing (for academic customers)
Service Description:
CRISPR-Cas9 technology enables the modification of genome to produce precise and unique knock-out and knock-in GM mouse models. Possible allele types that can be generated are indels, exon deletions (< 10kb), point mutations and insertions.