- decreased interleukin-10 secretion / MGI
- increased aggression towards males / MGI
- increased anxiety-related response / MGI
- decreased exploration in new environment / MGI
- abnormal liquid preference / MGI
- abnormal cardiovascular system physiology / MGI
- increased thermal nociceptive threshold / MGI
- increased heart rate / MGI
- increased systemic arterial blood pressure / MGI
- hypoalgesia / MGI
- abnormal locomotor activation / MGI
- increased body mass index / MGI
- increased platelet aggregation / MGI
- impaired behavioral response to alcohol / MGI
CD1.129-Adora2atm1Map/Cnbc
Status | Available to order |
EMMA ID | EM:10582 |
International strain name | CD1.129-Adora2atm1Map/Cnbc |
Alternative name | A2a KO outbred |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Adora2atm1Map, |
Gene/Transgene symbol | Adora2a |
Information from provider
Provider | Catherine LEDENT |
Provider affiliation | IRIBHM - Faculté de Médecine, Université Libre de Bruxelles |
Genetic information | Adenosine A2A receptor knockout. |
Phenotypic information | Homozygous:Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor, C. Ledent, J-M. Vaugeois, S. Schiffmann, T. Pedrazzini, M. EL Yacoubi, J.-J. Vanderhaegen, J. Costentin, J. K. Heath, G. Vassart and M. Parmentier, Nature (1997) 388, 674-678.Heterozygous:no phenotype |
Breeding history | Backcross CD1: HE x CD1 WT ; HE x CD1 WT .... (N >20) |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.), wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.;Ledent C, Vaugeois J M, Schiffmann S N, Pedrazzini T, El Yacoubi M, Vanderhaeghen J J, Costentin J, Heath J K, Vassart G, Parmentier M, ;1997;Nature;388;674-8; 9262401
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