CD1.129-Adora2atm1Map/Cnbc

Status

Available to order

EMMA IDEM:10582
International strain nameCD1.129-Adora2atm1Map/Cnbc
Alternative nameA2a KO outbred
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolAdora2atm1Map,
Gene/Transgene symbolAdora2a

Information from provider

ProviderCatherine LEDENT
Provider affiliationIRIBHM - Faculté de Médecine, Université Libre de Bruxelles
Genetic informationAdenosine A2A receptor knockout.
Phenotypic informationHomozygous:
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor, C. Ledent, J-M. Vaugeois, S. Schiffmann, T. Pedrazzini, M. EL Yacoubi, J.-J. Vanderhaegen, J. Costentin, J. K. Heath, G. Vassart and M. Parmentier, Nature (1997) 388, 674-678.

Heterozygous:
no phenotype
Breeding historyBackcross CD1: HE x CD1 WT ; HE x CD1 WT .... (N >20)
References
  • Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.;Ledent C, Vaugeois J M, Schiffmann S N, Pedrazzini T, El Yacoubi M, Vanderhaeghen J J, Costentin J, Heath J K, Vassart G, Parmentier M, ;1997;Nature;388;674-8; 9262401
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.), wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.)
Stage of embryos2-cell

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased interleukin-10 secretion / MGI
  • increased aggression towards males / MGI
  • increased anxiety-related response / MGI
  • decreased exploration in new environment / MGI
  • abnormal liquid preference / MGI
  • abnormal cardiovascular system physiology / MGI
  • increased thermal nociceptive threshold / MGI
  • increased heart rate / MGI
  • increased systemic arterial blood pressure / MGI
  • hypoalgesia / MGI
  • abnormal locomotor activation / MGI
  • increased body mass index / MGI
  • increased platelet aggregation / MGI
  • impaired behavioral response to alcohol / MGI

Literature references

  • Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.;Ledent C, Vaugeois J M, Schiffmann S N, Pedrazzini T, El Yacoubi M, Vanderhaeghen J J, Costentin J, Heath J K, Vassart G, Parmentier M, ;1997;Nature;388;674-8; 9262401

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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