B6.129-Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Oulu
| Status | Available to order |
| EMMA ID | EM:10892 |
| International strain name | B6.129-Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Oulu |
| Alternative name | Gt(ROSA)26Sortm1(LDLR/avidin)Svo or R26RLodavin |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm1(LDLR/avidin)Svo, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Seppo Vainio |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu |
| Genetic information | A loxP followed by a PGK-betageo construct, three SV40 polyA sites, and a second loxP site were inserted in the Gt(ROSA)26Sor locus, followed by a fused human low density lipoprotein receptor/avidin sequence. |
| Phenotypic information | Homozygous:as in wild typeHeterozygous:as in wild type |
| Breeding history | 5 backcrosses to C57BL/6 |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd |
Literature references
- Conditional expression of Lodavin, an avidin-tagged LDL receptor, for biotin-mediated applications in vivo.;Murugan Subramanian, Saarela Ulla, Airenne Kari, Shan Jingdong, Skovorodkin Ilya, Ylä-Herttuala Seppo, Vainio Seppo J, ;2012;Genesis (New York, N.Y. : 2000);50;693-9; 22467513