B6;129-Mapkapk2^tm1Gkl/Flmg

Status	Available to order
EMMA ID	EM:10944
International strain name	B6;129-Mapkapk2^tm1Gkl/Flmg
Alternative name	MK2FLneo/FLneo [129.B6-MapkapK2tm1Gkl/Flmg]
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Mapkapk2^tm1Gkl,
Gene/Transgene symbol	Mapkapk2

Information from provider

Provider	George Kollias
Provider affiliation	BSRC Fleming
Genetic information	MK2FLneo mice contain loxP sites 1/2 flanking a neomycin resistance gene fragment and loxP sites 2/3 flanking the area between exons 2-5 of the mouse Mapkapk2 gene.
Phenotypic information	Homozygous: No overt phenotype Heterozygous: No overt phenotype
References	Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis.;Henriques Ana, Koliaraki Vasiliki, Kollias George, ;2018;Proceedings of the National Academy of Sciences of the United States of America;115;E5546-E5555; 29844172
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	B.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archiving	homozygous C57BL/6

Literature references

Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis.;Henriques Ana, Koliaraki Vasiliki, Kollias George, ;2018;Proceedings of the National Academy of Sciences of the United States of America;115;E5546-E5555; 29844172

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6;129-Mapkapk2tm1Gkl/Flmg