B6.Cg-Map3k7tm1Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:11024 |
| International strain name | B6.Cg-Map3k7tm1Gkl/Flmg |
| Alternative name | B6.Cg-Map3k7 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Map3k7tm1Gkl, |
| Gene/Transgene symbol | Map3k7 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | B.S.R.C. |
| Genetic information | An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2, which encodes part of the kinase domain including the ATP binding pocket. An additional loxP site was inserted downstream of exon 2. |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6 |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cardiospondylocarpofacial syndrome / Orphanet_3238
- Frontometaphyseal dysplasia / Orphanet_1826
Literature references
- Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.;Eftychi Christina, Karagianni Niki, Alexiou Maria, Apostolaki Maria, Kollias George, ;2012;PloS one;7;e31550; 22348103