B6;129P2-Rhdtm1Goo/Orl
| Status | Available to order |
| EMMA ID | EM:11706 |
| International strain name | B6;129P2-Rhdtm1Goo/Orl |
| Alternative name | GOO1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rhdtm1Goo, |
| Gene/Transgene symbol | Rhd |
Information from provider
| Provider | Dominique GOOSSENS |
| Provider affiliation | UMR_S1134-Inserm - Dept de recherches biologiques sur le globule rouge, Institut National de la Transfusion Sanguine-Inserm |
| Genetic information | Rhd (erythroid membrane protein) gene knock-out. |
| Phenotypic information | Homozygous:No clinical or cellular abnormalities, complete loss of erythrocyte membrane expression of Rhd, and of Icam4 (with consequent decreased adhesion to endothelial cell line)Heterozygous:Normal |
| Breeding history | 129P2/OlaHsd x C57BL/6 |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous 129P2/OlaHsd x C57BL/6, wild-type C57BL/6 |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Rh deficiency syndrome / Orphanet_71275
Literature references
- Generation and characterisation of Rhd and Rhag null mice.;Goossens Dominique, Trinh-Trang-Tan Marie-Marcelle, Debbia Martine, Ripoche Pierre, Vilela-Lamego Camilo, Louache Fawzia, Vainchenker William, Colin Yves, Cartron Jean-Pierre, ;2010;British journal of haematology;148;161-72; 19807729
- Generation of mice with inactivated Rh or Rhag genes.;Goossens D, Bony V, Gane P, Colin Y, Cartron J-P, ;2006;Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine;13;164-6; 16581281