STOCK Vkorc1Y139C/H
| Status | Available to order |
| EMMA ID | EM:11995 |
| International strain name | STOCK Vkorc1Y139C/H |
| Alternative name | HM_Y139C |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Vkorc1Y139C, |
| Gene/Transgene symbol | Vkorc1 |
Information from provider
| Provider | Colin Prescott |
| Provider affiliation | Biological Sciences, University of Reading |
| Genetic information | House mouse homozygous for the Vkorc1 mutation Y139C. |
| Phenotypic information | Homozygous:This mutation confers a degree of resistance to anticoagulants, and in particular to the rodenticide anticoagulants.Heterozygous:The degree of resistance is greater for homozygous animals than for heterozygous animals. |
| Breeding history | Wild-derived house mice that possessed the Vkorc1 mutation Y139C were crossed with albino Swiss CD-1 house mice. The Y139C mutation was then transferred for six generations onto the albino Swiss CD-1 house mouse background, and then backcrossed to produce the homozygous strain. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary combined deficiency of vitamin K-dependent clotting factors / Orphanet_98434
Literature references
- The genetic basis of resistance to anticoagulants in rodents.;Pelz Hans-Joachim, Rost Simone, Hünerberg Mirja, Fregin Andreas, Heiberg Ann-Charlotte, Baert Kristof, MacNicoll Alan D, Prescott Colin V, Walker Anne-Sophie, Oldenburg Johannes, Müller Clemens R, ;2005;Genetics;170;1839-47; 15879509