HprtDll1ECD_Dll4ICD
| Status | Available to order |
| EMMA ID | EM:12228 |
| International strain name | HprtDll1ECD_Dll4ICD |
| Alternative name | HprtDll1ECD_Dll4ICD |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | HprtDll1ECD_Dll4ICD |
| Gene/Transgene symbol | Hprt1 |
Information from provider
| Provider | Achim Gossler |
| Provider affiliation | Molecular Biology, Medizinische Hochschule Hannover |
| Genetic information | Cre-inducible chimeric ligand (Dll1 ectodomain, Dll4 intracellular domain) introduced by homologous recombination into the Hprt locus; cre-mediated recombination removes stop cassette and leads to transgene expression |
| Phenotypic information | Homozygous:No phenotype unrecombined; recombined depending on cre lineHeterozygous:Viable; no phenotype |
| Breeding history | After germline transmission outcrossed to CD1, then crossed to CD1 |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) |
Literature references
- The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.;Tveriakhina Lena, Schuster-Gossler Karin, Jarrett Sanchez M, Andrawes Marie B, Rohrbach Meike, Blacklow Stephen C, Gossler Achim, ;2018;eLife;7;; 30289388