CD1;129-Hprt1tm7(CAG-Dll1/Dll4,-DsRed)Gos/Biat
| Status | Available to order |
| EMMA ID | EM:12229 |
| International strain name | CD1;129-Hprt1tm7(CAG-Dll1/Dll4,-DsRed)Gos/Biat |
| Alternative name | Hprt-Dll4ECD_Dll1ICD |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | CD1;129-Hprt1tm7(CAG-Dll1/Dll4, -DsRed)Gos |
| Gene/Transgene symbol | Hprt1 |
Information from provider
| Provider | Achim Gossler |
| Provider affiliation | Molecular Biology, Medizinische Hochschule Hannover |
| Genetic information | cre recombinase-inducible chimeric ligand (Dll4 ectodomain, Dll1 intracellular domain) introduced by homologous recombination into the Hprt1 locus; cre-mediated recombination removes the stop cassette and leads to transgene expression. |
| Phenotypic information | Homozygous:No phenotype if unrecombined; depending on cre recombinase-expressing line if recombined.Heterozygous:Viable; no phenotype. |
| Breeding history | After germline transmission outcrossed to CD1, then crossed to CD1. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous CD1 |
Literature references
- The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.;Tveriakhina Lena, Schuster-Gossler Karin, Jarrett Sanchez M, Andrawes Marie B, Rohrbach Meike, Blacklow Stephen C, Gossler Achim, ;2018;eLife;7;; 30289388