D2;B6-Tardbp^Rgsc2268/RgscH

Status	Available to order
EMMA ID	EM:12616
International strain name	D2;B6-Tardbp^Rgsc2268/RgscH
Alternative name	Tardbp RRM2mut (F210I) DBA
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Tardbp^Rgsc2268,
Gene/Transgene symbol	Tardbp

Information from provider

Provider	Yoichi Gondo
Provider affiliation	Department of Molecular Life Sciences, Tokai University School of Medicine
Genetic information	ENU induced point mutation, mouse Tardbp gene, "low complexity domain"; F210I (chr4:148,619,270 (mm10), T>A)
Phenotypic information	Homozygous: Assumed lethal. Homozygotes are lethal on B6 and B6 x DBA (F1). Heterozygous: None known
Breeding history	>10 generations on DBA/2 at MRC Harwell
References	ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system.;Gondo Yoichi, Fukumura Ryutaro, Murata Takuya, Makino Shigeru, ;2010;Experimental animals;59;537-48; 21030782 Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.;Fratta Pietro, Sivakumar Prasanth, Humphrey Jack, Lo Kitty, Ricketts Thomas, Oliveira Hugo, Brito-Armas Jose M, Kalmar Bernadett, Ule Agnieszka, Yu Yichao, Birsa Nicol, Bodo Cristian, Collins Toby, Conicella Alexander E, Mejia Maza Alan, Marrero-Gagliardi Alessandro, Stewart Michelle, Mianne Joffrey, Corrochano Silvia, Emmett Warren, Codner Gemma, Groves Michael, Fukumura Ryutaro, Gondo Yoichi, Lythgoe Mark, Pauws Erwin, Peskett Emma, Stanier Philip, Teboul Lydia, Hallegger Martina, Calvo Andrea, Chiò Adriano, Isaacs Adrian M, Fawzi Nicolas L, Wang Eric, Housman David E, Baralle Francisco, Greensmith Linda, Buratti Emanuele, Plagnol Vincent, Fisher Elizabeth Mc, Acevedo-Arozena Abraham, ;2018;The EMBO journal;37;; 29764981
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

ENU-based gene-driven mutagenesis in the mouse: a next-generation gene-targeting system.;Gondo Yoichi, Fukumura Ryutaro, Murata Takuya, Makino Shigeru, ;2010;Experimental animals;59;537-48; 21030782
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.;Fratta Pietro, Sivakumar Prasanth, Humphrey Jack, Lo Kitty, Ricketts Thomas, Oliveira Hugo, Brito-Armas Jose M, Kalmar Bernadett, Ule Agnieszka, Yu Yichao, Birsa Nicol, Bodo Cristian, Collins Toby, Conicella Alexander E, Mejia Maza Alan, Marrero-Gagliardi Alessandro, Stewart Michelle, Mianne Joffrey, Corrochano Silvia, Emmett Warren, Codner Gemma, Groves Michael, Fukumura Ryutaro, Gondo Yoichi, Lythgoe Mark, Pauws Erwin, Peskett Emma, Stanier Philip, Teboul Lydia, Hallegger Martina, Calvo Andrea, Chiò Adriano, Isaacs Adrian M, Fawzi Nicolas L, Wang Eric, Housman David E, Baralle Francisco, Greensmith Linda, Buratti Emanuele, Plagnol Vincent, Fisher Elizabeth Mc, Acevedo-Arozena Abraham, ;2018;The EMBO journal;37;; 29764981

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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D2;B6-TardbpRgsc2268/RgscH