STOCK Loxl2tm1.2Acan/2AcanCnbc
| Status | Available to order |
| EMMA ID | EM:12916 |
| International strain name | STOCK Loxl2tm1.2Acan/2AcanCnbc |
| Alternative name | Q |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Loxl2tm1.2Acan, |
| Gene/Transgene symbol | Loxl2 |
Information from provider
| Provider | Amparo Cano |
| Provider affiliation | Biochemistry, Autonoma University (Medicine Faculty) |
| Additional owner | Francisco Portillo and Alberto Martin, Universidad Autónoma de Madrid, Spain. |
| Genetic information | Constitutive Loxl2 knock-out. |
| Phenotypic information | Homozygous:Partial perinatal lethality due to cardiac and liver defects. Knock-out mice develop a lower number of skin tumors after being subjected to DMBA/TPA (dimethylbenz-anthracene and 12-O-tetradecanoyl phorbol-13-acetate) treatment.Heterozygous:Completely normal. |
| Breeding history | Obtained as CFB strain (EM:12882) from a different ES clone (#10). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous mixed, wild-type FVB/N |
| Stage of embryos | 2-cell |
Literature references
- Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.;Martin Alberto, Salvador Fernando, Moreno-Bueno Gema, Floristán Alfredo, Ruiz-Herguido Cristina, Cuevas Eva P, Morales Saleta, Santos Vanesa, Csiszar Katalin, Dubus Pierre, Haigh Jody J, Bigas Anna, Portillo Francisco, Cano Amparo, ;2015;The EMBO journal;34;1090-109; 25759215