STOCK Loxl2tm1.1Acan/Cnbc
Status | Available to order |
EMMA ID | EM:13005 |
International strain name | STOCK Loxl2tm1.1Acan/Cnbc |
Alternative name | AKB |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Loxl2tm1.1Acan, |
Gene/Transgene symbol | Loxl2 |
Information from provider
Provider | Amparo Cano |
Provider affiliation | Biochemistry, Autonoma University (Medicine Faculty) |
Additional owner | Francisco Portillo and Alberto Martin, Universidad Autónoma de Madrid, Spain. |
Genetic information | Loxl2 conditional knock-out. |
Phenotypic information | Homozygous:Normal; no remarkable phenotype.Heterozygous:Normal; no remarkable phenotype. |
Breeding history | Conditional knock-out mutation of Loxl2 based on cre/loxP system was introduced by homologous recombination in the endogenous locus of Loxl2. Positive ES clones for the mutation were microinjected/aggregated into receptive blastocysts/morulas and chimeras were obtained. These animals were crossed with wild-type mice in order to check germline transmision. The resultant heterozygous animals harbouring the conditional knock-out mutation were intercrossed and homozygous animals were obtained. |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | homozygous mixed, homozygous mixed |
Stage of embryos | 2-cell |
Literature references
- Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.;Martin Alberto, Salvador Fernando, Moreno-Bueno Gema, Floristán Alfredo, Ruiz-Herguido Cristina, Cuevas Eva P, Morales Saleta, Santos Vanesa, Csiszar Katalin, Dubus Pierre, Haigh Jody J, Bigas Anna, Portillo Francisco, Cano Amparo, ;2015;The EMBO journal;34;1090-109; 25759215
- Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.;Salvador Fernando, Martin Alberto, López-Menéndez Celia, Moreno-Bueno Gema, Santos Vanesa, Vázquez-Naharro Alberto, Santamaria Patricia G, Morales Saleta, Dubus Pierre R, Muinelo-Romay Laura, López-López Rafael, Tung Jason C, Weaver Valerie M, Portillo Francisco, Cano Amparo, ;2017;Cancer research;77;5846-5859; 28720577
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