B6(Cg)-Cacna1btm1.1Arte/H
| Status | Available to order |
| EMMA ID | EM:13038 |
| International strain name | B6(Cg)-Cacna1btm1.1Arte/H |
| Alternative name | CaV2.2_HA Knockin |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Cacna1bKI-HA |
| Gene/Transgene symbol | Cacna1b |
Information from provider
| Provider | Annette Dolphin |
| Provider affiliation | NPP, UCL |
| Genetic information | Constitutive knock-in of a 2xHA tag in the Cacna1b (CaV2.2) gene. |
| Phenotypic information | Homozygous:Homozygous CaV2.2_HA knock-in mice are not different phenotypically from wild-type mice but provide a tool to visualise endogenous CaV2.2 channels.Heterozygous:Heterozygous CaV2.2_HA knock-in mice are not different phenotypically from wild-type mice |
| Breeding history | Mutant mice generated by TaconicArtemis in 2014 and backcrossed to wild-type C57BL/6J several times since. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Undetermined early-onset epileptic encephalopathy / Orphanet_442835
Literature references
- Ablation of α2δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo.;Nieto-Rostro Manuela, Ramgoolam Krishma, Pratt Wendy S, Kulik Akos, Dolphin Annette C, ;2018;Proceedings of the National Academy of Sciences of the United States of America;115;E12043-E12052; 30487217