B6.129S2-Sulf2tm1Clrm/Ieg
| Status | Available to order |
| EMMA ID | EM:13163 |
| International strain name | B6.129S2-Sulf2tm1Clrm/Ieg |
| Alternative name | Sulf2tm1Clrm |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Sulf2tm1Clrm, |
| Gene/Transgene symbol | Sulf2 |
Information from provider
| Provider | Torben Lübke |
| Provider affiliation | Chemistry - Biochemistry, Bielefeld University |
| Genetic information | Targeted mutation (null/knockout) in the heparan sulfate 6-O-endosulfatase (Sulf2), sulfatase 2, gene. Mutation details: a neomycin resistance gene was inserted into exon 1. Northern blot confirmed absence of transcript in mutants. PMID:16901266 |
| Phenotypic information | Homozygous:See also http://www.informatics.jax.org/allele/allgenoviews/MGI:3699621 premature death ( J:116527 ) decreased body weight ( J:116527 ) abnormal brain morphology ( J:116527 )Heterozygous:No obvious phenotype |
| Breeding history | Backcrossed for at least 10 generations into C57BL/6JRccHsd |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6 |
Literature references
- Roles of heparan sulfate sulfation in dentinogenesis.;Hayano Satoru, Kurosaka Hiroshi, Yanagita Takeshi, Kalus Ina, Milz Fabian, Ishihara Yoshihito, Islam Md Nurul, Kawanabe Noriaki, Saito Masahiro, Kamioka Hiroshi, Adachi Taiji, Dierks Thomas, Yamashiro Takashi, ;2012;The Journal of biological chemistry;287;12217-29; 22351753
- Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.;Kalus Ina, Rohn Susanne, Puvirajesinghe Tania M, Guimond Scott E, Eyckerman-Kölln Pieter J, Ten Dam Gerdy, van Kuppevelt Toin H, Turnbull Jeremy E, Dierks Thomas, ;2015;PloS one;10;e0139853; 26448642
- Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development.;Ratzka Andreas, Kalus Ina, Moser Markus, Dierks Thomas, Mundlos Stefan, Vortkamp Andrea, ;2008;Developmental dynamics : an official publication of the American Association of Anatomists;237;339-53; 18213582
- Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.;Lamanna William C, Baldwin Rebecca J, Padva Michael, Kalus Ina, Ten Dam Gerdy, van Kuppevelt Toin H, Gallagher John T, von Figura Kurt, Dierks Thomas, Merry Catherine L R, ;2006;The Biochemical journal;400;63-73; 16901266
- Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair.;Korf-Klingebiel Mortimer, Reboll Marc R, Grote Karsten, Schleiner Hauke, Wang Yong, Wu Xuekun, Klede Stefanie, Mikhed Yuliya, Bauersachs Johann, Klintschar Michael, Rudat Carsten, Kispert Andreas, Niessen Hans W, Lübke Torben, Dierks Thomas, Wollert Kai C, ;2019;Circulation research;125;787-801; 31434553
- Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity.;Kalus Ina, Salmen Benedikt, Viebahn Christoph, von Figura Kurt, Schmitz Dietmar, D'Hooge Rudi, Dierks Thomas, ;2009;Journal of cellular and molecular medicine;13;4505-21; 20394677
- The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair.;Maltseva Inna, Chan Matilda, Kalus Ina, Dierks Thomas, Rosen Steven D, ;2013;PloS one;8;e69642; 23950901