Hint1xHint2 wild-type
| Status | Available to order |
| EMMA ID | EM:13168 |
| International strain name | Hint1xHint2 wild-type |
| Alternative name | Hint1xHint2 WT |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Hint1+ |
| Gene/Transgene symbol | Hint1 |
Information from provider
| Provider | Jean-Francois Dufour |
| Provider affiliation | DBMR Hepatology, University of Bern |
| Additional owner | Hint1 strain was a gift from Prof. Weinstein, NY USA |
| Genetic information | The doubly wild-type Hint2 x Hint1 mice were obtained by crossing Hint1 wild-type with Hint2 wild-type. |
| Phenotypic information | Homozygous:Wild-type animals show no specific phenotype.Heterozygous:Wild-type animals show no specific phenotype. |
| Breeding history | For Hint1-KO (EMMA strain ID EM:13223): ES cells heterozygous for the targeted mutation were microinjected into C57BL/6 blastocysts and implanted into pseudopregnant females. The resulting male chimeras were mated with female C57BL/6 mice. Germ-line transmission of the injected ES cells was confirmed by inheritance of the agouti coat color in the F1 mice, and the agouti offspring were tested for the presence of the mutated Hint1 allele by Southern blot analysis of tail DNA. These mice were backcrossed to 129 mice for several generations, so that in the Hint1-/- mice used in the present study over 96% of their background is from the 129 strain mice. For Hint2-KO (EMMA strain ID EM:13220): cre recombinase-mediated excision of the floxed Hint2 gene (deletion of exon 1 to exon 5). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | wild-type 129 x C57BL/6, wild-type 129 x C57BL/6 |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive axonal neuropathy with neuromyotonia / Orphanet_324442
Literature references
- Hint1 is a haplo-insufficient tumor suppressor in mice.;Li H, Zhang Y, Su T, Santella R M, Weinstein I B, ;2006;Oncogene;25;713-21; 16186798
- Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.;Su Tao, Suzui Masumi, Wang Lei, Lin Chyuan-Sheng, Xing Wang-Qiu, Weinstein I Bernard, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;7824-9; 12810953
- Ablation of the tumor suppressor histidine triad nucleotide binding protein 1 is protective against hepatic ischemia/reperfusion injury.;Martin Juliette, Romanque Pamela, Maurhofer Olivier, Schmitter Karin, Hora Caroline, Ferrand Gisèle, Dufour Jean-François, ;2011;Hepatology (Baltimore, Md.);53;243-52; 21140474
- Disruption of tumor suppressor gene Hint1 leads to remodeling of the lipid metabolic phenotype of mouse liver.;Beyoğlu Diren, Krausz Kristopher W, Martin Juliette, Maurhofer Olivier, Dorow Juliane, Ceglarek Uta, Gonzalez Frank J, Dufour Jean-François, Idle Jeffrey R, ;2014;Journal of lipid research;55;2309-19; 25193995