B6.129-Rnf2tm1Mvi/Cnbc
| Status | Available to order |
| EMMA ID | EM:13229 |
| Citation information | RRID:IMSR_EM:13229 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Rnf2tm1Mvi/Cnbc |
| Alternative name | Rnf2tm1Mvi |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Rnf2tm1Mvi |
| Gene/Transgene symbol | Rnf2 |
Information from provider
| Provider | Miguel Vidal |
| Provider affiliation | Centro de Investigaciones Biológicas Margarita Salas |
| Genetic information | loxP site 5' to first coding exon (exon) and loxP-flanked PGKneo cassette knocked in (antisense) into Rnf2 IVS 3 |
| Phenotypic information | Homozygous:None overt in general. Where best studied, i.e. bone marrow, hypo-cellularity without major consequencesHeterozygous:None obvious |
| Breeding history | Backcrossed 4-5 times into C57BL/6 |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
Literature references
- Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.;Calés Carmela, Román-Trufero Mónica, Pavón Leticia, Serrano Iván, Melgar Teresa, Endoh Mitsuhiro, Pérez Claudia, Koseki Haruhiko, Vidal Miguel, ;2008;Molecular and cellular biology;28;1018-28; 18039844