B6.129-Rnf2tm1Mvi/Cnbc
| Status | Available to order |
| EMMA ID | EM:13229 |
| International strain name | B6.129-Rnf2tm1Mvi/Cnbc |
| Alternative name | Rnf2tm1Mvi |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Rnf2tm1Mvi, |
| Gene/Transgene symbol | Rnf2 |
Information from provider
| Provider | Miguel Vidal |
| Provider affiliation | Centro de Investigaciones Biológicas Margarita Salas |
| Genetic information | loxP site 5' to first coding exon (exon) and loxP-flanked PGKneo cassette knocked in (antisense) into Rnf2 IVS 3 |
| Phenotypic information | Homozygous:None overt in general. Where best studied, i.e. bone marrow, hypo-cellularity without major consequencesHeterozygous:None obvious |
| Breeding history | Backcrossed 4-5 times into C57BL/6 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
Literature references
- Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion.;Calés Carmela, Román-Trufero Mónica, Pavón Leticia, Serrano Iván, Melgar Teresa, Endoh Mitsuhiro, Pérez Claudia, Koseki Haruhiko, Vidal Miguel, ;2008;Molecular and cellular biology;28;1018-28; 18039844