C57BL/6-Prkg1tm1Cya/H
| Status | Available to order |
| EMMA ID | EM:14907 |
| International strain name | C57BL/6-Prkg1tm1Cya/H |
| Alternative name | C195S PKG |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Prkg1tm1Cya |
| Gene/Transgene symbol | Prkg1 |
Information from provider
| Provider | Friederike Cuello |
| Provider affiliation | Universitätsklinikum Hamburg Eppendorf |
| Genetic information | C195S PKG mutant mice express a C195S mutant form of Prkg1 (PKG1). |
| Phenotypic information | Homozygous:Homozygous mutant mice have similar basal phenotype as wild-type littermates.Heterozygous:Heterozygous mutant mice have similar basal phenotype as wild-type littermates. |
| Breeding history | Mice were sib-mated 11 times and backcrossed 2 times to C57BL/6N. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3',5'-Monophosphate-Dependent Protein Kinase I.;Kamynina Alisa, Guttzeit Sebastian, Eaton Philip, Cuello Friederike, ;2022;Hypertension (Dallas, Tex. : 1979);79;946-956; 35168371