B6.Cg-Gt(ROSA)26Sor^{tm1.1(Ubc-Grn)Ite}/Ieg

Status	Available to order
EMMA ID	EM:15254
International strain name	B6.Cg-Gt(ROSA)26Sor^{tm1.1(Ubc-Grn)Ite}/Ieg
Alternative name	Gt(ROSA)26Sortm1.1(Ubc-Grn)Ite MGI:6149573
Strain type	Gene-trap
Allele/Transgene symbol	Rosa26 locus
Gene/Transgene symbol	Gt(ROSA)26Sor

Information from provider

Provider	Irmgard Tegeder
Provider affiliation	Clinical Pharmacology, Goethe University Frankfurt, Faculty of Medicine
Genetic information	A ubiquitin C promoter, a floxed stop cassette, mouse progranulin cDNA, and FRT flanked pgk-neo cassette were inserted via homologous recombination into the Gt(ROSA)26Sor locus. Flp mediated recombination removed the neo cassette. See reference: Altmann C, et al., Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy. Neurobiol Dis. 2016 Dec;96:294- 311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11. PMID: 27629805
Phenotypic information	Homozygous: None Heterozygous: None
Breeding history	Parent ES cell line: Bruce 4, strain of origin: B6.Cg-Thy1a. Crossed with C57BL/6. Bred as homozygous line (Grn-flfl) since 2015.
References	None available
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	yes
Immunocompromised	no

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany
Animals used for archiving	homozygous C57BL/6

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6.Cg-Gt(ROSA)26Sortm1.1(Ubc-Grn)Ite/Ieg