B6J.CBCa-Tg(Thy1-MAPT*P301S)2541Godt/H
| Status | Available to order |
| EMMA ID | EM:15269 |
| International strain name | B6J.CBCa-Tg(Thy1-MAPT*P301S)2541Godt/H |
| Alternative name | Tg(Thy1-MAPT*P301S)2541Godt |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Thy1-MAPT*P301S)2541Godt |
| Gene/Transgene symbol | Tg(Thy1-MAPT*P301S)2541Godt |
Information from provider
| Provider | Michel Goedert |
| Provider affiliation | MRC Laboratory of Molecular Biology |
| Genetic information | Homozygous for human 0N4R P301S Tau (MAPT) transgene (under Thy1.2 promoter). |
| Phenotypic information | Homozygous:Progressive impaired gait culminating in hindlimb paralysis around 7-8 months of age.Heterozygous:Same as for homozygous mice but delayed and with a wider window. Heterozygous mice usually reach end point between 12 and 20 months of age. |
| Breeding history | More than 10 backcrosses onto C57BL/6J background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.;Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K, Yoshida H, Holzer M, Craxton M, Emson PC, Atzori C, Migheli A, Crowther RA, Ghetti B, Spillantini MG, Goedert M.;2002;J Neurosci;22;9340-9351; 12417659