C57BL/6N-Phf8tm1.1Ics/Ics

Status

Available to order

EMMA IDEM:15623
International strain nameC57BL/6N-Phf8tm1.1Ics/Ics
Alternative namePhf8tm1.1Ics (G25)
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolPhf8tm1.1Ics
Gene/Transgene symbolPhf8

Information from provider

Provider ICS, Institut Clinique de la Souris
Provider affiliationICS, Institut Clinique de la Souris
Genetic informationThis line was obtained by modification of TB1 in house derived C57BL/6N embryonic stem cells. Exon 7 (ENSMUSE00000246773) was floxed. The flipped NeoR cassette was removed by breeding the male chimeras with flp recombinase deleter females. The line was generated on a pure C57BL/6N inbred genetic background. For detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
viable

Heterozygous:
DOI: 10.3390/biomedicines10123148
Breeding historyInbred C57BL/6N
References
  • Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • improved glucose tolerance / IMPC
  • abnormal eye anterior chamber depth / IMPC
  • decreased erythrocyte cell number / IMPC
  • abnormal heart left ventricle morphology / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • decreased lymphocyte cell number / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • increased circulating cholesterol level / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating LDL cholesterol level / IMPC
  • increased neutrophil cell number / IMPC

Literature references

  • Large-Scale Functional Assessment of Genes Involved in Rare Diseases with Intellectual Disabilities Unravels Unique Developmental and Behaviour Profiles in Mouse Models.;Meziane Hamid, Birling Marie-Christine, Wendling Olivia, Leblanc Sophie, Dubos Aline, Selloum Mohammed, Pavlovic Guillaume, Sorg Tania, Kalscheuer Vera M, Billuart Pierre, Laumonnier Frédéric, Chelly Jamel, van Bokhoven Hans, Herault Yann, ;2022;Biomedicines;10;; 36551904

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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