B6CBACa-Tg(RP1-309F20*)48Kel/H
| Status | Available to order |
| EMMA ID | EM:01707 |
| International strain name | B6CBACa-Tg(RP1-309F20*)48Kel/H |
| Alternative name | Tg(RP1-309F20)48Kel |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(RP1-309F20*)48Kel, |
| Gene/Transgene symbol | Tg(RP1-309F20*)48Kel |
Information from provider
| Provider | Gavin Kelsey |
| Provider affiliation | The Babraham Institute, Babraham, Cambridge, CB2 4PB |
| Genetic information | The transgene contains the human clone PAC RP1-309F20 with the GNAS1 (guanine nucleotide binding protein, alpha stimulating 1) locus (from chr. 20q13). In this locus the candidate imprinting control element, containing the promoter of the NESPAS (antisense to Nesp) regulatory antisense transcript, has been flanked by loxP sites. Created by pronuclear injection into fertilized oocytes. |
| Phenotypic information | The candidate imprinting control element, containing the promoter of the NESPAS regulatory antisense transcript, has been flanked by loxP sites. Upon crossing to cre recombinase-expressing transgenic lines the regulatory element can be deleted, thereby uncovering the function of the candidate element in the regulation of expression and imprinting of the GNAS1 locus. |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |