STOCK Igf2tm4Wrk/H
Status | Available to order |
EMMA ID | EM:01732 |
International strain name | STOCK Igf2tm4Wrk/H |
Alternative name | S1.2Neo |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Igf2tm4Wrk, |
Gene/Transgene symbol | Igf2 |
Information from provider
Provider | Dr Wolf Reik |
Provider affiliation | The Babraham Institute, Babraham, Cambridge, CB2 4PB |
Genetic information | Replacement vector containing a floxed neo-resistance gene, causing a small knock-out in a silencer region of the mouse Igf2 gene in a repressor protein binding site and leading to relative derepression of Igf2. |
Phenotypic information | Intra-uterine growth restriction (paternal transmission). Loss of imprinting (maternal transmission). |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Isolated hemihyperplasia / Orphanet_2128
- Silver-Russell syndrome due to a point mutation / Orphanet_397590
MGI phenotypes (allele matching)
Literature references
- An upstream repressor element plays a role in Igf2 imprinting.;Eden S, Constancia M, Hashimshony T, Dean W, Goldstein B, Johnson A C, Keshet I, Reik W, Cedar H, ;2001;The EMBO journal;20;3518-25; 11432838
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