MGI phenotypes (allele matching)
STOCK Bmp7tm1Rob/H
| Status | Available to order |
| EMMA ID | EM:02198 |
| International strain name | STOCK Bmp7tm1Rob/H |
| Alternative name | Bmp7 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Bmp7tm1Rob, |
| Gene/Transgene symbol | Bmp7 |
Information from provider
| Provider | Elizabeth Robertson |
| Provider affiliation | Sir William Dunn School of Pathology, University of Oxford |
| Genetic information | A genomic fragment containing the first coding exon and approximately 150 bp of upstream sequence was replaced by a neomycin resistance cassette. RNAse protection assays did not detect any transcripts produced from this allele in homozygous mice. |
| Phenotypic information | This strain is a null allele of BMP7 generated by replacing the BMP7 coding sequence by a neomycin cassette. BMP7 is required in the metanephric mesenchyme of the developing kidney to support maintenance of this cell population during organogenesis. Homozygous lethal at birth due to kidney agenesis. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.;Dudley A T, Lyons K M, Robertson E J, ;1995;Genes & development;9;2795-807; 7590254