C57BL/6-Tg(CAG-LEPROT)1Blll/Orl
| Status | Available to order |
| EMMA ID | EM:02245 |
| International strain name | C57BL/6-Tg(CAG-LEPROT)1Blll/Orl |
| Alternative name | Tg (CMV-ACTB/hLEPROT) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CAG-LEPROT)1Blll, |
| Gene/Transgene symbol | Tg(CAG-LEPROT)1Blll |
Information from provider
| Provider | Bernard BAILLEUL |
| Provider affiliation | INSERM University Lille2 |
| Genetic information | Randomly expressed; ubiquitous promoter. Protein expression in liver and muscle has been confirmed by Western blot. |
| Phenotypic information | Growth retardation, decreased liver growth hormone sensitivity. |
| Breeding history | Direct additive transgenic in inbred C57BL/6. The transgene and the phenotype are stable since at least 5 generations. |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous , wild-type C57BL/6J |
Literature references
- The leptin receptor promoter controls expression of a second distinct protein.;Bailleul B, Akerblom I, Strosberg A D, ;1997;Nucleic acids research;25;2752-8; 9207021
- Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking.;Belgareh-Touzé Naïma, Avaro Sandrine, Rouillé Yves, Hoflack Bernard, Haguenauer-Tsapis Rosine, ;2002;Molecular biology of the cell;13;1694-708; 12006663
- LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.;Touvier Thierry, Conte-Auriol Françoise, Briand Olivier, Cudejko Céline, Paumelle Réjane, Caron Sandrine, Baugé Eric, Rouillé Yves, Salles Jean-Pierre, Staels Bart, Bailleul Bernard, ;2009;The Journal of clinical investigation;119;3830-8; 19907080