C57BL/6-Tg(CAG-LEPROTL1)1Blll/Orl
Status | Available to order |
EMMA ID | EM:02246 |
International strain name | C57BL/6-Tg(CAG-LEPROTL1)1Blll/Orl |
Alternative name | Tg (CMV-ACTB/hLEPROTL1) |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(CAG-LEPROTL1)1Blll, |
Gene/Transgene symbol | Tg(CAG-LEPROTL1)1Blll |
Information from provider
Provider | Bernard BAILLEUL |
Provider affiliation | INSERM University Lille2 |
Genetic information | Randomly expressed; ubiquitous promoter. Protein expression in liver and muscle has been confirmed by Western blot. |
Phenotypic information | Growth retardation, decreased liver growth hormone sensitivity. |
Breeding history | Direct additive transgenic in inbred C57BL/6. The transgene and the phenotype are stable since at least 5 generations. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Literature references
- Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking.;Belgareh-Touzé Naïma, Avaro Sandrine, Rouillé Yves, Hoflack Bernard, Haguenauer-Tsapis Rosine, ;2002;Molecular biology of the cell;13;1694-708; 12006663
- Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1).;Huang Y, Ying K, Xie Y, Zhou Z, Wang W, Tang R, Zhao W, Zhao S, Wu H, Gu S, Mao Y, ;2001;Biochimica et biophysica acta;1517;327-31; 11342119
- LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice.;Touvier Thierry, Conte-Auriol Françoise, Briand Olivier, Cudejko Céline, Paumelle Réjane, Caron Sandrine, Baugé Eric, Rouillé Yves, Salles Jean-Pierre, Staels Bart, Bailleul Bernard, ;2009;The Journal of clinical investigation;119;3830-8; 19907080
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