C3H.Cg-Ankrd11Yod/H

Status

Available to order

EMMA IDEM:00380
International strain nameC3H.Cg-Ankrd11Yod/H
Alternative nameGENA110
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolAnkrd11Yod,
Gene/Transgene symbolAnkrd11

Information from provider

ProviderPat Nolan
Provider affiliationMRC Mammalian Genetics Unit
Genetic informationA GC-to-AT transition point mutations in exon 11 results in a glutamine to lysine substitution in a highly conserved residue in the encoded protein.
Phenotypic informationMice carrying the GENA110 mutation have craniofacial abnormalities and late on-set osteoporosis.
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • mammalian phenotype / IMPC
  • decreased bone mineral density / IMPC
  • decreased body weight / IMPC
  • abnormal response to new environment / IMPC
  • abnormal retinal vasculature morphology / IMPC
  • abnormal bone mineralization / IMPC
  • abnormal bone structure / IMPC
  • increased lean body mass / IMPC
  • decreased circulating amylase level / IMPC
  • increased total body fat amount / IMPC
MGI phenotypes (allele matching)
  • decreased bone mineral density / MGI
  • abnormal nasal bone morphology / MGI
  • kyphosis / MGI
  • domed cranium / MGI
  • increased cranium width / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • abnormal craniofacial bone morphology / MGI
  • abnormal bone structure / MGI
  • abnormal metopic suture morphology / MGI
  • decreased bone mass / MGI
  • short frontal bone / MGI
  • enlarged parietal bone / MGI
  • short nasal bone / MGI
  • decreased osteoclast cell number / MGI
  • decreased circulating leptin level / MGI
  • abnormal frontonasal suture morphology / MGI
  • decreased compact bone area / MGI
  • short face / MGI
  • broad face / MGI
  • decreased embryo size / MGI
  • failure of initiation of embryo turning / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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