129S2.Cg-Tg(KRT10-Igf2r*)KippsGfc/H
| Status | Available to order |
| EMMA ID | EM:04336 |
| Citation information | RRID:IMSR_EM:04336 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S2.Cg-Tg(KRT10-Igf2r*)KippsGfc/H |
| Alternative name | K10s(delta)Igf2r / Kipps |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(KRT10-Igf2r*)KippsGfc |
| Gene/Transgene symbol | Tg(KRT10-Igf2r*)KippsGfc |
Information from provider
| Provider | Bass Hassan |
| Provider affiliation | Medical Oncology, University of Oxford |
| Additional owner | The original producer of this strain has transferred sole ownership rights to Prof. Bass Hassan |
| Genetic information | Transgene expressing a truncated, soluble form of Igf2r cDNA from the bovine homolog of the keratin-10 promoter. The Kipps line exhibits the highest transgene expression. |
| Phenotypic information | Slightly reduced overall body weight, disproportionate reduction in size of alimentary canal and uterus. |
| Breeding history | Backcrossed onto 129S2 for at least 20 generations, currently bred heterozygous male x wild-type female. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous 129S2/SvPas males |
| Breeding at archiving centre | None |
Literature references
- Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor.;Zaina S, Newton R V, Paul M R, Graham C F, ;1998;Endocrinology;139;3886-95; 9724044
- The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms.;Zaina S, Squire S, ;1998;The Journal of biological chemistry;273;28610-6; 9786853
- Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.;Harper James, Burns Jason L, Foulstone Emily J, Pignatelli Massimo, Zaina Silvio, Hassan A Bassim, ;2006;Cancer research;66;1940-8; 16488992