129S2.Cg-Tg(KRT10-Igf2r*)KippsGfc/H

Status	Available to order
EMMA ID	EM:04336
International strain name	129S2.Cg-Tg(KRT10-Igf2r*)KippsGfc/H
Alternative name	K10s(delta)Igf2r / Kipps
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(KRT10-Igf2r*)KippsGfc,
Gene/Transgene symbol	Tg(KRT10-Igf2r*)KippsGfc

Information from provider

Provider	Bass Hassan
Provider affiliation	Medical Oncology, University of Oxford
Additional owner	The original producer of this strain has transferred sole ownership rights to Prof. Bass Hassan
Genetic information	Transgene expressing a truncated, soluble form of Igf2r cDNA from the bovine homolog of the keratin-10 promoter. The Kipps line exhibits the highest transgene expression.
Phenotypic information	Slightly reduced overall body weight, disproportionate reduction in size of alimentary canal and uterus.
Breeding history	Backcrossed onto 129S2 for at least 20 generations, currently bred heterozygous male x wild-type female.
References	Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor.;Zaina S, Newton R V, Paul M R, Graham C F, ;1998;Endocrinology;139;3886-95; 9724044 The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms.;Zaina S, Squire S, ;1998;The Journal of biological chemistry;273;28610-6; 9786853 Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.;Harper James, Burns Jason L, Foulstone Emily J, Pignatelli Massimo, Zaina Silvio, Hassan A Bassim, ;2006;Cancer research;66;1940-8; 16488992
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous 129S2/SvPas
Breeding at archiving centre	None

Literature references

Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor.;Zaina S, Newton R V, Paul M R, Graham C F, ;1998;Endocrinology;139;3886-95; 9724044
The soluble type 2 insulin-like growth factor (IGF-II) receptor reduces organ size by IGF-II-mediated and IGF-II-independent mechanisms.;Zaina S, Squire S, ;1998;The Journal of biological chemistry;273;28610-6; 9786853
Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.;Harper James, Burns Jason L, Foulstone Emily J, Pignatelli Massimo, Zaina Silvio, Hassan A Bassim, ;2006;Cancer research;66;1940-8; 16488992

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.