CD1.129-Nodaltm1Rob/Orl
Status | Available to order |
EMMA ID | EM:04858 |
International strain name | CD1.129-Nodaltm1Rob/Orl |
Alternative name | 129 Nodal-LacZ (KO) |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Nodaltm1Rob, |
Gene/Transgene symbol | Nodal |
Information from provider
Provider | Elizabeth Robertson |
Provider affiliation | CNRS UMR7592 Universite Paris 6 et 7, Institut Jacques Monod |
Additional owner | Dr. Jerome Collignon, Institut Jacques Monod, Paris, France |
Genetic information | Insertion of IRES-betaGeob (beta-galactosidase + neomycin resistance) into the second exon of the Nodal gene. |
Phenotypic information | Mutant embryos fail to gastrulate and die at E8.0. |
Breeding history | This mutation was first generated and maintained on a 129 background before being backcrossed and maintained on a CD1 background (N>10). |
References |
|
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.), wild-type CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.) |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Situs inversus totalis / Orphanet_101063
- Alobar holoprosencephaly / Orphanet_93925
- Midline interhemispheric variant of holoprosencephaly / Orphanet_93926
- Microform holoprosencephaly / Orphanet_280200
- Septopreoptic holoprosencephaly / Orphanet_280195
- Semilobar holoprosencephaly / Orphanet_220386
- Lobar holoprosencephaly / Orphanet_93924
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- decreased embryo size / MGI
- embryonic growth arrest / MGI
- abnormal developmental patterning / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal extraembryonic tissue morphology / MGI
- prenatal lethality, complete penetrance / MGI
- abnormal heart looping / MGI
- absent notochord / MGI
- abnormal gastrulation / MGI
- abnormal gastrulation movements / MGI
- abnormal primitive node morphology / MGI
- abnormal rostral-caudal axis patterning / MGI
- abnormal visceral endoderm morphology / MGI
- fused somites / MGI
- embryonic-extraembryonic boundary constriction / MGI
Literature references
- A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.;Collignon J, Sockanathan S, Hacker A, Cohen-Tannoudji M, Norris D, Rastan S, Stevanovic M, Goodfellow P N, Lovell-Badge R, ;1996;Development (Cambridge, England);122;509-20; 8625802
- Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo.;Camus Anne, Perea-Gomez Aitana, Moreau Anne, Collignon Jérôme, ;2006;Developmental biology;295;743-55; 16678814
- Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning.;Mesnard Daniel, Guzman-Ayala Marcela, Constam Daniel B, ;2006;Development (Cambridge, England);133;2497-505; 16728477
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