CBACa;129P2-Prkab1Gt(RRR454)Byg/WtsiCnbc

Status

Available to order

EMMA IDEM:05013
International strain nameCBACa;129P2-Prkab1Gt(RRR454)Byg/WtsiCnbc
Alternative namePrkab1 genetrap
Strain typeGene-trap
Allele/Transgene symbolPrkab1Gt(RRR454)Byg,
Gene/Transgene symbolPrkab1

Information from provider

ProviderKaren Steel
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThe line was generated from the BayGenomics ES cell RRR454.
Phenotypic informationHomozygotes tend to die before weaning. Minor phenotypic defects in heterozygotes.
Breeding historyThe chimaeras were generated from 129P2/OlaHsd ES cells, then crossed to CBA/Ca and intercrossed since.
ReferencesNone available
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI phenotypes (allele matching)
  • tremors / MGI
  • decreased brain size / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal dentate gyrus morphology / MGI
  • abnormal cerebellum morphology / MGI
  • absent cerebellar granule layer / MGI
  • abnormal myelination / MGI
  • decreased body weight / MGI
  • abnormal optic nerve morphology / MGI
  • ataxia / MGI
  • seizures / MGI
  • abnormal astrocyte morphology / MGI
  • loss of hippocampal neurons / MGI
  • astrocytosis / MGI
  • abnormal neuronal precursor proliferation / MGI
  • abnormal axon morphology / MGI
  • optic nerve hypoplasia / MGI
  • brain vacuoles / MGI
  • abnormal dendrite morphology / MGI
  • slow postnatal weight gain / MGI
  • decreased cerebellar granule cell number / MGI
  • decreased neuron number / MGI
  • decreased oligodendrocyte number / MGI
  • abnormal neuron differentiation / MGI
  • postnatal lethality, complete penetrance / MGI
  • cerebellum atrophy / MGI

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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