- tremors / MGI
- decreased brain size / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal dentate gyrus morphology / MGI
- abnormal cerebellum morphology / MGI
- absent cerebellar granule layer / MGI
- abnormal myelination / MGI
- decreased body weight / MGI
- abnormal optic nerve morphology / MGI
- ataxia / MGI
- seizures / MGI
- abnormal astrocyte morphology / MGI
- loss of hippocampal neurons / MGI
- astrocytosis / MGI
- abnormal neuronal precursor proliferation / MGI
- abnormal axon morphology / MGI
- optic nerve hypoplasia / MGI
- brain vacuoles / MGI
- abnormal dendrite morphology / MGI
- slow postnatal weight gain / MGI
- decreased cerebellar granule cell number / MGI
- decreased neuron number / MGI
- decreased oligodendrocyte number / MGI
- abnormal neuron differentiation / MGI
- postnatal lethality, complete penetrance / MGI
- cerebellum atrophy / MGI
CBACa;129P2-Prkab1Gt(RRR454)Byg/WtsiCnbc
Status | Available to order |
EMMA ID | EM:05013 |
International strain name | CBACa;129P2-Prkab1Gt(RRR454)Byg/WtsiCnbc |
Alternative name | Prkab1 genetrap |
Strain type | Gene-trap |
Allele/Transgene symbol | Prkab1Gt(RRR454)Byg, |
Gene/Transgene symbol | Prkab1 |
Information from provider
Provider | Karen Steel |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | The line was generated from the BayGenomics ES cell RRR454. |
Phenotypic information | Homozygotes tend to die before weaning. Minor phenotypic defects in heterozygotes. |
Breeding history | The chimaeras were generated from 129P2/OlaHsd ES cells, then crossed to CBA/Ca and intercrossed since. |
References | None available |
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Disease and phenotype information
MGI phenotypes (allele matching)
Information on how we integrate external resources can be found here
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