STOCK Nbr1tm2Whca/H
| Status | Available to order |
| EMMA ID | EM:06115 |
| International strain name | STOCK Nbr1tm2Whca/H |
| Alternative name | Nbr1D50R |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Nbr1tm2Whca, |
| Gene/Transgene symbol | Nbr1 |
Information from provider
| Provider | Caroline Whitehouse |
| Provider affiliation | Medical and Molecular Genetics, King |
| Genetic information | Targeted knock-in mutation in 129Sv-derived DNA clone of single amino acid residue 50 of Nbr1 causing amino acid change D to R. |
| Phenotypic information | Point mutation disrupts Nbr1-p62 PB1 mediated protein interaction. Phenotype of altered bone remodelling: increased osteoclast differentiation and resulting early osteoporotic phenotype |
| Breeding history | Currently bred as homozygous strain for D50R mutation. Mice have not been backcrossed or outcrossed but inbred with siblings or mice on same mixed background and are still on mixed background. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |