B6;CBA-Tg(TNFRSF1B)1335Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:09003 |
| International strain name | B6;CBA-Tg(TNFRSF1B)1335Gkl/Flmg |
| Alternative name | CBA.B6-Tg(TNFRSF1B)1335Gkl/Flmg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(TNFRSF1B)1335Gkl |
| Gene/Transgene symbol | Tg(TNFRSF1B)1335Gkl |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | The Tg1335 mice contain as transgene a 70 kb DNA fragment comprising the entire human TNFR2 (TNFRSF1B) genomic sequence. |
| Phenotypic information | Homozygous:Homozygous mice develop a severe pathology characterized by multi-organ inflammation, reduced weight gain, runting, lethargy, and premature lethality.Heterozygous:Heterozygous TgE1335 mice overexpress human TNFR2 (TNFRSF1B) in a physiologically relevant pattern and develop a chronic but mild peri-vascular inflammatory pathology in liver, pancreas, and lung at 2-3 months. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous CBA x C57BL/6 |
Literature references
- A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.;Douni E, Kollias G, ;1998;The Journal of experimental medicine;188;1343-52; 9763613